Team:NYMU-Taipei/project/2c
From 2014.igem.org
communication
The third "C" product, "Communication."
The two main organisms we adapted in our project are Escherichia coli and M102bacteriophage, respectively. Our team comes up with an interesting thought that we want to let these two entirely different organisms collaborate,thus we decided to use one of the most commonly seen quorum sensing chemicals, AHL, N-Acyl homoserine lactone, as our indicator between phage and E.coli.
Purpose
Due to the idea of phage threshold control of the number of Streptococcus mutans in prevention of the second-dominant strain in the oral cavity, we envision a possibility to trigger another killing system to reach synergistic effect on diminishing S.mutans.<p/> <p>If the threshold terminators were passed, the downstream signaling pathway would be switched on and contact with the engineered E.coli.