Team:Exeter/TheProblem

From 2014.igem.org

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<h1> The Problem </h1>
<h1> The Problem </h1>
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<p>TNT has been used as an explosive since 1902.By the end of the 20th century over 1000 tons of TNT were being produced each year in the USA alone. The health implications of exposure to TNT are well known. Unfortunately TNT pollution is not one that goes away! Though the chemical does break down, at a WWI ammunitions destruction facility in Belgium TNT remnants were found to be present in soil over 80 years after its closure.</p>
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<p>TNT has been used as an explosive since 1902, and quickly became widely used in warfare and demolition; in World War Two over 1 million tonnes was produced by the Allies alone. Although production has fallen since then over 1000 tonnes per annum are produced just by the USA.</p>
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<p>There are consequences to this high level of production. The waste created when producing TNT is toxic and long-lasting; the soil around a World War One ammunition disposal facility in Belgium was found to still contain high levels of TNT and related compounds.</p>
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<p><b>Health implications:</b></p>
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<h2>What implications does TNT have for health?</h2>
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<li>Chronic exposure to TNT can cause a syndrome that puts the sufferer at an increased risk of leukemia. In Marburg, Germany residents living close to a WWII ammunition plant that left ground soil contaminated with TNT were 10x more likely to die of leukemia than the national average. A study conducted on copper miners that used TNT in their work found they were 4.5x more likely to develop urinary tract tumors and 14.3x more at risk of kidney tumors. This mutagenic effect has also been seen in mice.
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<li><b>Chronic exposure to TNT can put the sufferer at an increased risk of leukaemia.</b> In Marburg, Germany residents living close to contaminated ground soil from a WWII ammunition plant 10 times more likely to die of leukaemia than the national average. A study conducted on copper miners that used TNT in their work found they were 4.5 times more likely to develop urinary tract tumours and 14.3 times more at risk of kidney tumours. This mutagenic effect has also been observed in mice.
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</li>
<li>
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Prolonged TNT exposure can cause cataracts. An Israeli study showed that 50% of people had developed the illness after 7 years exposure on average. In a Chinese study that tracked munitions workers who had been exposed to TNT for 20 years, 88.4% of the workers had developed peripheral, cataracts.
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<b>Prolonged TNT exposure can cause cataracts.</b> An Israeli study showed that 50% of people had developed the illness after 7 years exposure on average. In a Chinese study that tracked munitions workers who had been exposed to TNT for 20 years, 88.4% of the workers had developed peripheral cataracts.
</li>
</li>
<li>  
<li>  
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Accute exposure to TNT results in a 1-8% increase in methemoglobin levels in the blood. This can last for 2-5 days. Methemoglobin is dangerous as it is unable to bind oxygen – meaning that oxygen cannot be released into the blood. This may result in tissue hypoxia.
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Acute exposure to TNT results in a <b>1-8% increase in methemoglobin levels in the blood</b>. This can last for 2-5 days. Methemoglobin is dangerous as it is unable to bind oxygen – meaning that oxygen cannot be released into the blood and can result in tissue hypoxia.
</li>
</li>
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<p>There have also been multiple studies in animals that show negative effects on fertility, development of dermatitis, anemia and spleen damage.</p>
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<p>There have also been multiple studies in animals that show TNT can cause:</p>
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<ul>
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<p>Exposure to TNT occurs in many places across the world. The main cause of TNT pollution is through military exercises. Mining, laboratory research and unused munitions sites also contribute towards the pollution. There are 100s of TNT polluted sites in America alone. In Europe and Asia these numbers are even higher. Here are some specific examples of situations where the legacy of TNT pollution has created public health problems:</p>
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<li>Negative effects on fertility</li>
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<li>Development of dermatitis</li>
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<li>Anaemia </li>
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<li>Spleen damage.</li>
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</ul>
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<br>
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<p>Exposure to TNT occurs in many places across the world. The main cause of TNT pollution is through waste created at TNT production sites. A significant level of pollution is also created through military exercises and mining activites. There are hundreds of TNT polluted sites in America alone , with thousands of sites worldwide.</p>
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<p>TNT Production/Disposal facilities present such a threat to health due to the lack of regulation and care taken in the past when working with these compounds; common practice around the world was to allow all “pink water”, heavily contaminated waste water produced during the creation of TNT, to run off into lagoons built into the environment. Current TNT production facilities do not pose a significant threat to health, due to higher safety standards.</p>
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<p><b>The legacy of TNT pollution is widespread:</b></p>
<ul>
<ul>
<li>
<li>
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In Germany an ammunition factory from WWII produced over 5 million cubic meters of TNT. This resulted in polluted ground water over the course of xx years.  
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In Germany an ammunition factory from WWII produced over 5 million litres of TNT. This resulted in polluted ground water, and there is a risk to health which must be dealt with by the water treatment plant.  
</li>
</li>
<li>
<li>
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Closer to home, England created 12 munitions factories during WWI and another 16 in WWII. These factories all produced toxic TNT waste. In addition to this during the wars many bombs containing TNT were dropped on the country, in one year alone during WWII it is approximated that this accounted for about 100 tons.
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Closer to home, England was supplied by 12 munitions factories during WWI and another 16 in WWII, all producing toxic TNT waste. In addition to this during the wars many bombs containing TNT-based explosives were dropped on the country; in one year alone during WWII this accounted for approximately 100 tons of TNT.
</li>
</li>
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</ul>
 
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<p>Unused munitions are difficult to dispose of. This results in dumping sites. At Beau forts Dyke, Scotland over 1 million tons of used munitions have been dumped into the ocean. Many of these munitions are explosive contaminated and at risk of causing exposure around the Scottish coastline. There are 9 smaller-scale dumping sites in Scotland and another 12 in England. </p>
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<li>Unused munitions are difficult to dispose of. This has resulted in dumping sites. At Beaufort’s Dyke, Scotland over 1 million tons of used munitions have been dumped into the ocean. Many of these munitions are contaminated with explosives and risk causing exposure to these compounds around the Scottish coastline. There are a further 9 smaller-scale dumping sites in Scotland and another 12 in England. </li>
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</ul>

Revision as of 01:08, 17 October 2014

Exeter | ERASE

The Problem

TNT has been used as an explosive since 1902, and quickly became widely used in warfare and demolition; in World War Two over 1 million tonnes was produced by the Allies alone. Although production has fallen since then over 1000 tonnes per annum are produced just by the USA.

There are consequences to this high level of production. The waste created when producing TNT is toxic and long-lasting; the soil around a World War One ammunition disposal facility in Belgium was found to still contain high levels of TNT and related compounds.


What implications does TNT have for health?

  • Chronic exposure to TNT can put the sufferer at an increased risk of leukaemia. In Marburg, Germany residents living close to contaminated ground soil from a WWII ammunition plant 10 times more likely to die of leukaemia than the national average. A study conducted on copper miners that used TNT in their work found they were 4.5 times more likely to develop urinary tract tumours and 14.3 times more at risk of kidney tumours. This mutagenic effect has also been observed in mice.
  • Prolonged TNT exposure can cause cataracts. An Israeli study showed that 50% of people had developed the illness after 7 years exposure on average. In a Chinese study that tracked munitions workers who had been exposed to TNT for 20 years, 88.4% of the workers had developed peripheral cataracts.
  • Acute exposure to TNT results in a 1-8% increase in methemoglobin levels in the blood. This can last for 2-5 days. Methemoglobin is dangerous as it is unable to bind oxygen – meaning that oxygen cannot be released into the blood and can result in tissue hypoxia.

There have also been multiple studies in animals that show TNT can cause:

  • Negative effects on fertility
  • Development of dermatitis
  • Anaemia
  • Spleen damage.

Exposure to TNT occurs in many places across the world. The main cause of TNT pollution is through waste created at TNT production sites. A significant level of pollution is also created through military exercises and mining activites. There are hundreds of TNT polluted sites in America alone , with thousands of sites worldwide.

TNT Production/Disposal facilities present such a threat to health due to the lack of regulation and care taken in the past when working with these compounds; common practice around the world was to allow all “pink water”, heavily contaminated waste water produced during the creation of TNT, to run off into lagoons built into the environment. Current TNT production facilities do not pose a significant threat to health, due to higher safety standards.


The legacy of TNT pollution is widespread:

  • In Germany an ammunition factory from WWII produced over 5 million litres of TNT. This resulted in polluted ground water, and there is a risk to health which must be dealt with by the water treatment plant.
  • Closer to home, England was supplied by 12 munitions factories during WWI and another 16 in WWII, all producing toxic TNT waste. In addition to this during the wars many bombs containing TNT-based explosives were dropped on the country; in one year alone during WWII this accounted for approximately 100 tons of TNT.
  • Unused munitions are difficult to dispose of. This has resulted in dumping sites. At Beaufort’s Dyke, Scotland over 1 million tons of used munitions have been dumped into the ocean. Many of these munitions are contaminated with explosives and risk causing exposure to these compounds around the Scottish coastline. There are a further 9 smaller-scale dumping sites in Scotland and another 12 in England.
Exeter | ERASE

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