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Team:TU Eindhoven/Achievements/Submitted Parts/COMPx
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| + | <h2>COMPx</h2> | ||
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| + | <h3>Usage and Biology</h3> | ||
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<figcaption style="font-size:18px;color:#CCCCCC;">Figure 1. Structure of OmpX alongside a topological depiction of OmpX and CPX.</figcaption> | <figcaption style="font-size:18px;color:#CCCCCC;">Figure 1. Structure of OmpX alongside a topological depiction of OmpX and CPX.</figcaption> | ||
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<p>CPX, or Circularly permuted OmpX, was developed as a bacterial display methodology for N- and C- terminal display. It has been shown to enable rapid screening of very large peptide libraries with high precision and efficiency. OmpX possesses four extracellular loops, with loops 2 and 3 forming a semi rigid β-sheets protruding from the cell surface. The native N- and C-termini were fused together by a GGSG linker, and the newly formed N and C termini reside on the cell surface. | <p>CPX, or Circularly permuted OmpX, was developed as a bacterial display methodology for N- and C- terminal display. It has been shown to enable rapid screening of very large peptide libraries with high precision and efficiency. OmpX possesses four extracellular loops, with loops 2 and 3 forming a semi rigid β-sheets protruding from the cell surface. The native N- and C-termini were fused together by a GGSG linker, and the newly formed N and C termini reside on the cell surface. | ||
</p> | </p> | ||
Revision as of 13:54, 14 October 2014
COMPx
Usage and Biology
CPX, or Circularly permuted OmpX, was developed as a bacterial display methodology for N- and C- terminal display. It has been shown to enable rapid screening of very large peptide libraries with high precision and efficiency. OmpX possesses four extracellular loops, with loops 2 and 3 forming a semi rigid β-sheets protruding from the cell surface. The native N- and C-termini were fused together by a GGSG linker, and the newly formed N and C termini reside on the cell surface.
