"
Team:SCUT/Model/Overview
From 2014.igem.org
| Line 16: | Line 16: | ||
<body> | <body> | ||
<div id="left"> | <div id="left"> | ||
| - | <div class="navihead"> | + | <div class="navihead navihead1"> |
<img src="https://static.igem.org/mediawiki/2014/d/dc/1-01.png"> | <img src="https://static.igem.org/mediawiki/2014/d/dc/1-01.png"> | ||
</div> | </div> | ||
| Line 24: | Line 24: | ||
<p>N-butanol simulation</p> | <p>N-butanol simulation</p> | ||
</div> | </div> | ||
| - | <div class="navihead"> | + | <div class="navihead navihead2"> |
<img src="https://static.igem.org/mediawiki/2014/0/0c/2-01.png"> | <img src="https://static.igem.org/mediawiki/2014/0/0c/2-01.png"> | ||
</div> | </div> | ||
| - | <div class="navibody" onclick="scroll_1()"> | + | <div class="navibody navibody2" onclick="scroll_1()"> |
| - | <p> | + | <p>Individual part</p> |
| - | <p>Rubisco | + | <p>Combine part</p> |
| - | <p> | + | <p>The function of Rubisco</p> |
| + | <p>Scaffold</p> | ||
</div> | </div> | ||
| - | <div class="navihead"> | + | <div class="navihead navihead3"> |
<img src="https://static.igem.org/mediawiki/2014/1/16/3-01.png"> | <img src="https://static.igem.org/mediawiki/2014/1/16/3-01.png"> | ||
</div> | </div> | ||
| - | <div class="navibody" onclick="scroll_1()"> | + | <div class="navibody navibody3" onclick="scroll_1()"> |
<p>Background</p> | <p>Background</p> | ||
<p>Rubisco simulation</p> | <p>Rubisco simulation</p> | ||
<p>N-butanol simulation</p> | <p>N-butanol simulation</p> | ||
</div> | </div> | ||
| - | <div class="navihead"> | + | <div class="navihead navihead4"> |
<img src="https://static.igem.org/mediawiki/2014/a/ab/4-01.png"> | <img src="https://static.igem.org/mediawiki/2014/a/ab/4-01.png"> | ||
</div> | </div> | ||
| - | <div class="navibody" onclick="scroll_1()"> | + | <div class="navibody navibody4" onclick="scroll_1()"> |
<p>Background</p> | <p>Background</p> | ||
<p>Rubisco simulation</p> | <p>Rubisco simulation</p> | ||
<p>N-butanol simulation</p> | <p>N-butanol simulation</p> | ||
</div> | </div> | ||
| - | <div class="navihead"> | + | <div class="navihead navihead5"> |
<img src="https://static.igem.org/mediawiki/2014/7/7f/5-01.png"> | <img src="https://static.igem.org/mediawiki/2014/7/7f/5-01.png"> | ||
</div> | </div> | ||
| - | <div class="navibody" onclick="scroll_1()"> | + | <div class="navibody navibody5" onclick="scroll_1()"> |
<p>Background</p> | <p>Background</p> | ||
<p>Rubisco simulation</p> | <p>Rubisco simulation</p> | ||
Revision as of 09:33, 7 October 2014
Background
The design and redesign is one of the hallmarks of synthesis biology. In order to test the consistence of the pathway we designed and the function of scaffold we used, modeling is the most powerful tool to be used before doing experiments.
Rubisco part
For the Rubisco part, we use ODEs (ordinary differential equations) to simulate the pathway and proof the function of Rubisco. With the help of parameter sweep, we find out the optimal reaction rate ratio of the reactions involved in the scaffold. By the way ,we also use the“bottom-up” strategy, the most famous principle of Computer Science, to guide our work.
N-butanol part
For the N-butanol part, in order to simulate the n-butanol biosynthetic pathway in Saccharomyces cerevisiae mitochondria, we construct a model by using Michealis-Menton kinetics and ODEs (ordinary differential equations). The model shows that, with high concentrations of NADH and NADPH in mitochondria, the production of n-butanol will be greatly improved.
Besides, all of our programs run on the MATLAB.
