Team:Glasgow/Modeling

From 2014.igem.org

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<a href="https://2014.igem.org/wiki/index.php?title=Team:Glasgow/Modelling_Intro">intro to modelling</a>
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<strong> Section 1: Modelling of Bacteria Random Walk </strong><br>
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Firstly, we created a very basic 2D model of a flagella propelled bacterium. This was heavily based on the “random walk” model we mentioned previously, only we introduced a small degree of order, based on a more extensive and all-encompassing model created by Dillon, Fauci and Gaver in 1995.(link to paper?)DOI: 10.1006/jtbi.1995.0251 <br>
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<br>
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In order to simplify the model, we made a number of assumptions.  These are:<br>
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<ul>
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<li>Tumbling is instantaneous</li>
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<li>Chemotaxic gradient is not a factor</li>
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<li>An E.coil cell can be represented as a sphere</li>
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<li>Speed is constant (20ms<sup>-1</sup>)
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</ul>
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<br>
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The movement of a bacteria through a medium is described thus:<br>
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1. The bacteria is moving at a random angle at a certain speed.<br>
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2. After a certain time (the “run” time), the bacteria reorientates itself (the “tumble”), and sets off at a different angle.  This run time can be influenced by the chemotaxic gradient, if present
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Revision as of 14:33, 6 August 2014

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Section 1: Modelling of Bacteria Random Walk
Firstly, we created a very basic 2D model of a flagella propelled bacterium. This was heavily based on the “random walk” model we mentioned previously, only we introduced a small degree of order, based on a more extensive and all-encompassing model created by Dillon, Fauci and Gaver in 1995.(link to paper?)DOI: 10.1006/jtbi.1995.0251

In order to simplify the model, we made a number of assumptions. These are:
  • Tumbling is instantaneous
  • Chemotaxic gradient is not a factor
  • An E.coil cell can be represented as a sphere
  • Speed is constant (20ms-1)

The movement of a bacteria through a medium is described thus:
1. The bacteria is moving at a random angle at a certain speed.
2. After a certain time (the “run” time), the bacteria reorientates itself (the “tumble”), and sets off at a different angle. This run time can be influenced by the chemotaxic gradient, if present