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Team:Calgary/Project/BsDetector/TargetDiseases
From 2014.igem.org
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<h1>Target Diseases</h1> | <h1>Target Diseases</h1> | ||
<h3><i>A trend of forced misdiagnosis</i></h3> | <h3><i>A trend of forced misdiagnosis</i></h3> | ||
| - | <p>Febrile illnesses which pose symptoms similar to malaria are of particular concern in malaria-endemic countries. Patients who present symptoms such as fever, nausea, and headache are often suspected to have malaria before a diagnosis is even made due to malaria's prevalence in these regions. The tragedy lies in the fact that patients who test negative for malaria are often given antimalarial drugs despite their diagnosis, | + | <p>Febrile illnesses which pose symptoms similar to malaria are of particular concern in malaria-endemic countries. Patients who present symptoms such as fever, nausea, and headache are often suspected to have malaria before a diagnosis is even made due to malaria's prevalence in these regions. The tragedy lies in the fact that patients who test negative for malaria are often given antimalarial drugs and considered to have malaria despite their diagnosis. The over-prescription of antimalarials fosters an environment for drug resistance, unnecessarily taxes healthcare systems, and most importantly, worsens the patient's condition. Clinicians in malaria-endemic countries are presented with a dilemma as healthcare professionals when a patient with symptoms similar to malaria is revealed to actually not have the disease through commonly used diagnostics such as the Rapid Diagnostic Test(RDT) and microscopic blood smears. They must make an important decision based on limited information, the consequences of which could have severe effects on the patient. On one hand, they know that their patient most likely does not have malaria based on the tests, but on the other, they do not have the diagnostic means to explore the possibility of other diseases and they know that missing a case of malaria is considered unforgivable. Some clinicians will opt to treat all cases of fever, nausea, etc. as malaria and indiscriminately prescribe anti-malarial drugs, consequently ensuring that no case of malaria goes unaddressed. The ramifications of such practice can be tremendous, as we have seen in Sub-Saharan Africa. Unfortunately, those who appreciate the consequences of over-prescription and wish to consider alternative diagnoses are left with very few diagnostic options due to limitations on time and resources. They must ask themselves the question, "if it's not malaria, then what is it?". |
Revision as of 01:09, 15 October 2014
Target Diseases
A trend of forced misdiagnosis
Febrile illnesses which pose symptoms similar to malaria are of particular concern in malaria-endemic countries. Patients who present symptoms such as fever, nausea, and headache are often suspected to have malaria before a diagnosis is even made due to malaria's prevalence in these regions. The tragedy lies in the fact that patients who test negative for malaria are often given antimalarial drugs and considered to have malaria despite their diagnosis. The over-prescription of antimalarials fosters an environment for drug resistance, unnecessarily taxes healthcare systems, and most importantly, worsens the patient's condition. Clinicians in malaria-endemic countries are presented with a dilemma as healthcare professionals when a patient with symptoms similar to malaria is revealed to actually not have the disease through commonly used diagnostics such as the Rapid Diagnostic Test(RDT) and microscopic blood smears. They must make an important decision based on limited information, the consequences of which could have severe effects on the patient. On one hand, they know that their patient most likely does not have malaria based on the tests, but on the other, they do not have the diagnostic means to explore the possibility of other diseases and they know that missing a case of malaria is considered unforgivable. Some clinicians will opt to treat all cases of fever, nausea, etc. as malaria and indiscriminately prescribe anti-malarial drugs, consequently ensuring that no case of malaria goes unaddressed. The ramifications of such practice can be tremendous, as we have seen in Sub-Saharan Africa. Unfortunately, those who appreciate the consequences of over-prescription and wish to consider alternative diagnoses are left with very few diagnostic options due to limitations on time and resources. They must ask themselves the question, "if it's not malaria, then what is it?". We researched a wide spectrum of infectious diseases symptomatically similar to malaria and common throughout the world and decided to target the following diseases using our multiplexed diagnostic device:
- Typhoid fever
- Dengue fever
- Meningitis
- Pneumonia
- Visceral leishmaniasis Our device was designed with a
