Team:Oxford/what are microcompartments
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- | <h1white> | + | <h1white>Predicting the microcompartment structure</h1white> |
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- | + | The pdu microcompartments which we are introducing into our bacteria are very similar in shape and structure to carboxysomes. Because carboxysomes have been studied in far greater detail, we used their structure as a starting point for predicting the microcompartment structure. Thus, as a starting point, our initial structure was a perfect icosahedron with diameter 120nm as established from literature. Following this, we further developed the model by noting that many of the images taken of pdu microcompartments suggested slight deviations from an icosahedron although these deviations appeared random. | |
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+ | Taking this into consideration, we have developed a simulation which generates pdu microcompartment structures by starting with a regular icosahedron and randomly distorting the location of each co-ordinate by up to 5% of total edge length. | ||
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+ | Given more time and information, this model could be further improved by studying as many microcompartments as possible and refining the size of the deviation from a perfect icosahedron. The magnitude of structural deformation likely follows a normal distribution for which a mean and standard deviation could be established. | ||
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+ | An example microcompartment structure (blue) visualized alongside a perfect icosahedral structure (red). | ||
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Revision as of 07:12, 28 September 2014
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