Team:Evry

From 2014.igem.org

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<h1>Welcome to the <b><span style="color:#bb8900">Sponge Patrol</span></b> Home Page</h1>
 
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<p align="center"><b> The wiki is under heavy construction. <b></p>
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<p align="center"><b>The aim of our team this year is to design and realize a <em>filtration system</em> allowing to <em>detect and degrade polluants present in water</em>. </b></p>
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<h3 align="center">The Team</h3>
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<img src="https://static.igem.org/mediawiki/2014/9/9c/Evry2014Team.jpeg" alt="team photo" width="100%"/>
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<h3 align="center">Abstract</h3>
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<p>Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Vestibulum tortor quam, feugiat vitae, ultricies eget, tempor sit amet, ante. Donec eu libero sit amet quam egestas semper. Aenean ultricies mi vitae est. Mauris placerat eleifend leo. Quisque sit amet est et sapien ullamcorper pharetra. Vestibulum erat wisi, condimentum sed, commodo vitae, ornare sit amet, wisi. Aenean fermentum, elit eget tincidunt condimentum, eros ipsum rutrum orci, sagittis tempus lacus enim ac dui. Donec non enim in turpis pulvinar facilisis. Ut felis. Praesent dapibus, neque id cursus faucibus, tortor neque egestas augue, eu vulputate magna eros eu erat. Aliquam erat volutpat. Nam dui mi, tincidunt quis, accumsan porttitor, facilisis luctus, metus</p>
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Our project focuses on developing a novel treatment for <a href="https://2013.igem.org/Team:Evry/Project_diseases"><em>hematological disorders</em></a>  caused by an <a href="https://2013.igem.org/Team:Evry/Project_metabolism"><em>iron overload</em></a>, such as hemochromatosis and thalassemia. These autosomal recessive disorders have symptoms including cirrhosis, arthritis, and heart failure, which result from overabsorption of iron from the duodenum. Although these are among the most common heritable diseases, treatment options are limited. Even today patients are mostly treated by frequent bloodletting, which <a href="https://2013.igem.org/Team:Evry/HumanPractice/Patients_perceptions"><em>many people cannot support</em></a>. The aim of our project is to combat these diseases at the source by developing a therapy that prevents the intestinal absorption of iron.
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We engineer the <i>Escherichia coli</i> <a href="https://2013.igem.org/Team:Evry/Project_FUR"><em>Ferric Uptake Regulation</em></a> (FUR) system using a <a href="https://2013.igem.org/Team:Evry/Inverter"><em>genetic inverter</em></a> so that they produce siderophores (<a href="https://2013.igem.org/Team:Evry/Chelator"><em>iron chelators</em></a>) in response of high concentrations of iron. These engineered bacteria are delivered to the patient's intestine by encapsulating them in an ingestible polymer (<a href="https://2013.igem.org/Team:Evry/Pill_design"><em>capsule</em></a>)  that specifically degrades in the duodenum. Once released into the intestine, the bacteria respond to ambient iron by secreting elevated levels of siderophores, thereby chelating the iron to prevent its absorption by the patient.
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<h3 align="center">Overview of the project and the achievements</h3>
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alert("Our team is proud to announce that we were awarded a gold medal and the Best Human Practice price at the european jamboree! We are going to Boston.\n\nUnfortunately, we are missing a few thousands of euros to be capable of finishing the competition. If you are a company and would like to sponsor our team, please contact us at igemevry@gmail.com.")
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Latest revision as of 03:34, 18 October 2014

IGEM Evry 2014

IGEM Evry 2014

Welcome visitor !

Click on this interactive figure to explore our project

Abstract

The sponge can filtrate up to 20m3 of water/day/kg making it one of the most powerful filtrating system alive. Pseudovibrio denitrificans has been shown to be part of several sponges microbiome. Our project is based on the engineering of this bacterium in order to develop a filtrating system allowing to sense and even degrade pollutants in water when cooperating with sponges.


17
Team members
2
Biobricks
3
Collaborations
239+
All-nighters

Spon-ge-sors

Donators

Nicolas Cornille, Yves Mansoulie, Kevin Berenger, Benoît Monjanel, Pierre Parutto, Laurence Catatao, Hélène Gontier, Fatouma Sanou, Paul Besançon, Adrien Isidore, Diane Thomas, Odile Boyer, Julie Zaworski, Bernard Jesop, Jean-Louis Leuci, Hélène Dumant, Maurice Gontier, Aurélie Bérenger, Sylvie Currias, Maximin Rousseill, Florian Duval, Bastien Maysseng, Samuel Parmentier, Muriel Walter, Xavier Ferbeck, Béatrice Besançon, Alain Bauer, Gérard Vilarem.
Contacts

Retrieved from "http://2014.igem.org/Team:Evry"