Team:Heidelberg/Modeling

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Latest revision as of 03:04, 18 October 2014

– Quantitative insights

LINKER MODELING

The design of linkers, which are essential for our intein-based circularization and assembly methods, is a complicated task. Here we employ structural modeling and statistical analyses to guide our linker experiments and their design.

ENZYME KINETICS MODELING

Based on over 1000 degradation curves of our circularized lysozyme variants, we tried to interpret the effect of linkers on protein thermostability. This was achieved by use of quantitative dynamical modeling.

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+    <a href="/Team:Heidelberg/Modeling/Linker_Modeling" class="box" style="display:block; width:100%;">
+      <h2><span>LINKER MODELING</span></h2>
+       The design of linkers, which are essential for our intein-based circularization and assembly methods, is a complicated task. Here we employ structural modeling and statistical analyses to guide our linker experiments and their design.
+<div class="clearfix"></div>
+    </a>
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+</br>
    <div style="width:100%;padding:0 15px 0 15px;">
-     <a href="/Team:Heidelberg/Team/Members" class="box" style="display:block; width:30%;">
+     <a href="/Team:Heidelberg/Modeling/Enzyme_Modeling" class="box" style="display:block; width:100%;">
+      <h2><span>ENZYME KINETICS MODELING</span></h2>
+      Based on over 1000 degradation curves of our circularized lysozyme variants, we tried to interpret the effect of linkers on protein thermostability. This was achieved by use of quantitative dynamical modeling.
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-    <a href="/Team:Heidelberg/Team/Sponsoring" class="box" style="display:block">
-    <h3><span>Sponsoring</span></h3>
-   Our project is funded in part by the sponsors below. Without them, our work would not be possible.
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