Economical View

The economical considerations regarding our project were carried out according to the motto:

Make the world a better place - Open access for scientific progress

In the center of every economic analysis are the customers and their needs and desires. Every commercial company is interested in satisfying and dealing with all customer needs for better sales figures, in order to maintain regular clientele. Both measures aim for higher financial profits. On the global seller’s market of technical laboratory equipment there is a permanent competition between the existing providers. On the one hand, this competition depends on the mentioned financial profits and, on the other hand, on the following factors: technical improvement followed by price wars. Due to globalization products from the Asian market are increasingly competing with the American and European market resulting in intensitief price wars. On the Asian market personnel and production costs are much less and thus the same product can be sold with higher profits. Some of these products are less expensive but are often of lower quality, too. However, for a company it is important to chose a good price-performance ratio because this factor always catch customers and influence their purchase decision.

Costs and operating expenses for companies producing technical laboratory equipment (Thermo Fisher Scientific, 2013)

Take a look at cost calculations for technical laboratory equipment including development, production, transport, warehousing and sale. Usually, you will find that in this branche there are really low costs for research and development, restruction and amorthilisation. In contrast, general expenses and costs for administartion, revenues, and sales are high. Lastly, financial profit is a big cost point cause businesses have to be self-financing. In general, these factors are making technical equipment for labs really expensive, and therefore unaffordable for low budget instutions.

One of the world's biggest producers of laboratory products is [http://www.thermofisher.com/en/home.html Thermo Fisher Scientific]. They also offer photometers and other equipment. The image on the left side shows all costs and operating expenses listed in the [http://ir.thermofisher.com/investors/financial-information/annual-reports/default.aspx Annual Report 2013] from Thermo Fisher Scientific.

We follow a strategy to circumvent unnecessary costs for customers by realizing a social vision. In accordance with the principle of open source including both open hardware and open software, information where to get the necessary components, quantities, step-by-step technical construction manuals and circuit diagrams are published online for free. Potential customers can follow our given instructions and acquire information from our Engineering page. Therefore, our profit is not of financial nature but is instead based on recognition and on motivating other iGEM teams and companies to spread the idea of open hardware, too. In accordance with the motto "Do it yourself!" we offer low budget versions through reducing costs at as many points as possible, except for the basic costs for material. Customers with a little technical dexterity, motivation to try something new and that are keen to experiment can follow our step-by-step construction manual to create their own custom-made devices.

Social vision as economical strategy for creating access to low-budget technical equipment.

To make our product more user-friendly, we considered offering device kits. When offering kits customers do not have to order a lot of separate device parts from different suppliers. However, this introduces the disadvantage of a loss of flexibility. Yet it is very important to have the opportunity to modify the devices, for example, by choosing alternative parts or including add-ons, because research requiring novel techniques advances quickly in the natueral sciences. With our concept, improvements and adjustments are thus immediately realizable.

At least we want to mention that our vision is limited in getting acceptance by companies on the global seller market and we know about this problem. These companies, parts of them global players, are profit orientated and following another firm strategy. Our vision is standing against this as non-profit-idea finding acceptance in other groups of customers with lower budgets and just open view of fiancial aspects.

WatsOn

The measurement device WatsOn for our 2D biosensor, too, has been designed accordingly. So far, no comparable devices could be found on the commercial market. Here, we definitely have a pioneer role. Following our do-it-yourself method everybody can create his own WatsOn for 310 $ using the given building instructions. Starting with the order of needed components followed by assembling the different parts. Components for rebuliding are easy availible all over the world using the folowing links.

Such low prices with the acceptance of self-building opens a grand new customer market and offers competition to commercial saleable products. Especially in developing counties our WatsOn could help and its low rebuilding costs are making purchase possible. Such those low material costs and the high technical flexibility are making WatsOn to an adequate device for developing countries, community labs and the biohacker scene. In particular for developing countries such a low budget device version bids a good alternative to regular devices for detecting pathogens. With our device institutions in such those countries have an access to modern technology and working methods.

WatsOn's self-made concept makes it available for low budged institutions

Also for this device we are offering the building plan and also the needed software Measuraty for use. This makes it for institutions and also for amateurs possible to modify the device according to personal progress including for example the range of detectable micro-organisms. As an example it could be possible to detect not just the fluorescent of GFP and iLOV but also important reporter-proteins YFP, CFP or RFP. This would just be possible by changing the filter slides or LEDs.

However, please always remind yourself of the respective safety aspects when dealing with GMOs and human pathogens.

OD/F Device

One of our greater visions we share with the synthetic biology community is that everyone interested in biological work should have access to basic laboratory equipment. With our OD/F Device we are able to offer a low cost solution for community labs, biohackers and high schools.

Advantages and Disadvantes of our OD/F Device compared to commercial availiable devices

In general we have to make a difference between our OD and our F device. The reason for this is the bad comparability to commercial devices. These don't combine the measure of fluorescence and OD. With our OD/F we offer a solution to combine both measurement methods in one device. With our given instructions it is also possible to build two separate devices one for OD and one for F. In this context we offer the user a higher flexibility of choice during the user is also able to modify our device according to his own ideas and wishes.

Commercially obtainable spectrophotometers like [http://www.opticsplanet.com/unico-model-s-1205-spectrophotometer-5-nm-bandpass.html UNICO S-1205], for example, costs 1.249 $ or more, and can measure optical density only. At the same time they are heavy, not portable and therefore not easy to handle. Specially the portability is beside the low costs a big poitive point which allows new rages of applications. But compared to our device it is able to work with a broader range of wavelengths and it has a higher accuracy and precision. Besides commercial [http://www.moleculardevices.com/systems/microplate-readers/fluorescent-readers/gemini-xps plate reader] are also available on the market, too. To compare our device with this comercial devices is really difficult because no portable devices like ours could be found which can also measure at a wave-band of 480 nm.

Comparable to our developed device in the points measuring range and portability is the OD-meter [http://www.laboratory-equipment.com/laboratory-equipment/cell-density-meter.php CO 8000]. This device measures also the OD at 600 nm but still costs almost 920 $. Our OD/F Device can measure OD as well as fluorescence for less than 60 $ like the following chart is showing. Cost saving lies here round about 850 $. Money that could definetly be given some better utilizations like into other projects. One weakness of our device is the low reliability compared to commercial devices. This is because of the used low cost materials. Prices are given in $ and € for better accoutability and conversion.

All you have to do is to order the needed parts from the list above, invest some time and have technnical skills to construct our OD/F Device. It's still this aspect which could also have simultanious a positive learning effect for people in schools and universities and so on. Therefore, we present a solution for low budget institutions like schools, universities, community labs and the biohacking scene.

Possible application of our OD/F device

In our cooperation with the Kaiser-Karls-Gymnasium and with NEAnderLab one of our target groups gathered first experience using our OD/F Device. As result we received the answer of our question if the device is useable in daily practice with teenagers. And we got a positive feedback for this. Even young people are able to use and understand our device without any security risk like mentioned on our safty page.

References

Annual report. (2013). Thermo Fisher Scientific. Available at http://ir.thermofisher.com/investors/financial-information/annual-reports/default.aspx.