2D Biosensor

Cellock Holmes is devised based upon a SynBio approach comprised of a two-dimensional biosensor and a measurement device. The two-dimensional biosensor is designed to recognize quorum sensing molecules secreted by the pathogen cells and generate a distinct fluorescence signal, while the measurement device is designed to recognize and analyse the produced signal.

For our biosensor, our team genetically modified E. coli cells to be able to elecit a fluorescent response to quorum sensing molecules produced by the pathogen Pseudomonas aeruginosa.