• TRACKS:
• ENERGY
• ENVIRONMENT
• FOOD AND NUTRITION
• FOUNDATIONAL ADVANCE
• HEALTH AND MEDICINE
• INFORMATION PROCESSING
• MANUFACTURING
• NEW APPLICATION
  
  
• NEW TRACKS:
• Introduction
• Awards
• Requirements
• ART AND DESIGN
  • Introduction
  • Project brief
  • Requirements
  • Medal Criteria
  • Cross-Track Prize
  • Committee
• COMMUNITY LABS
  • Introduction
  • Track Details
  • Requirements
  • Medal Criteria
  • Committee
• ENTREPRENEURSHIP
• Introduction
• Previous competitions
• Previous teams
• Requirements
• Medal Criteria
• Committee
• MEASUREMENT
• Introduction
• Track Details
• Requirements
• Interlab Study
• Medal Criteria
• Committee
• MICROFLUIDICS
  • Introduction
  • Requirements
  • Medal Criteria
  • Committee
  • References
• POLICY AND PRACTICES
• Introduction
• Track Details
• Exemplar Projects
• Medal Criteria
• Committee
• SOFTWARE
• Introduction
• Track Details
• Resources
• Requirements
• Medal Criteria
• Committee

iGEM 2014 Manufacturing Track

• iGEM 2013 Manufacturing team list
• iGEM 2012 Manufacturing team list
• iGEM 2011 Manufacturing team list

Recent Manufacturing projects to win best in track

Winning Manufacturing projects in 2013 Undergrad:

Project abstract:

Winning Manufacturing projects in 2013 Overgrad:

Project abstract

Winning Manufacturing project in 2012: Arachnicoli

Utah State

Project abstract : Spider silk is the strongest known biomaterial, with a large variety of applications. These applications include artificial tendons and ligaments, biomedical sutures, athletic gear, parachute cords, air bags, and other yet discovered products which require a high tensile strength with amazing extendibility. Spiders however cannot be farmed because they are territorial and cannibalistic. Thus, an alternative to producing spider silk must be found. We aim to engineer spider silk genes into E. coli to produce this highly valuable product. Spider silk production in bacteria has been limited due to the highly repetitive nature of the spider silk amino acids in the protein. To overcome this obstacle we are using various synthetic biology techniques to boost spider silk protein production and increase cellular fitness. After successful production, spider silk protein is artificially spun into usable fibers and tested for physical properties.

Winning Manufacturing project 2011: Biofactory

Cornell

Project abstract: Cornell's 2011 iGEM team has designed a new, scalable, and cell-free method to produce complex biomolecules. Current methods for purification from cellular lysate are expensive and time consuming. Biofactory utilizes modified enzymes, capable of being attached to surfaces, in the creation of a modular microfluidic chip for each enzyme. The surface bonding is performed by the well characterized biotin-avidin mechanism. When combined in series, these chips operate as a linear biochemical pathway for continous flow reactions. Additionally, we engineered E. Coli with the mechanism for light-induced apoptosis to easily lyse cultures producing the necessary enzymes. The resulting lysate is flowed through the microfluidic channels, coating them with the desired enzyme. We believe these methods will reduce unwanted side reactions, and lower the costs of producing bio-pharmaceuticals in the future.