Team:UC Davis/Electrochemistry

The Electrochemistry team acquired, selected, and optimized an electrode setup for the detection of NADH at low concentrations in a complex solution. Additionally, the team demonstrated the ability of the electrode setup to detect enzyme generated NADH over time, and thereby functionally deconvolute aldehyde profiles within a sample.

Having settled on NAD⁺ dependent Aldehyde Dehydrogenases as our method of differentiating between aldehydes, we needed to develop an efficient electrode system to detect enzyme activity via NADH.
Our Electrode system needed to:

• Sensitive: have a low limit of detection for NADH
• Reactive: Detect NADH with high linear range
• Selective: Be robust to any possible solution components
• Affordable: Cost accessible to the average consumer
• Be efficient: Use a low sample volume
• Be compatible: Be compatible with our, as well as other potentiostats
• Be portable

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