Team:UiOslo Norway/

From 2014.igem.org

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<p>Meet mORGAN, the MicroOrganizer that keeps your project steady.</p>
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<p>Meet mORGAN, the MicroOrganizer that keeps your project steady.</p>
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<h3>About the project.</h3>
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<p>What if we could use bacterial layers as an organ?</p>
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<p>What if we could use bacterial layers as an organ?</p>
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<p>What if we could use these bacteria to make small organs of human or environmentally needed products? This is what our project is all about.</p>
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<p>What if we could use these bacteria to make small organs of human or environmentally needed products? This is what our project is all about.</p>
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<p>We will make distinctive layers of bacteria cells expression different properties of our organ. The bacterial layers will be held together by protein complementation; Different parts of the protein will be expressed on the surface of each bacterial layer. The protein parts work a bit as puzzle pieces – they only stick together when it is a perfect match. By this puzzle based system we will make organized layers of cells.</p>
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<p>We will make distinctive layers of bacteria cells expression different properties of our organ. The bacterial layers will be held together by protein complementation; Different parts of the protein will be expressed on the surface of each bacterial layer. The protein parts work a bit as puzzle pieces – they only stick together when it is a perfect match. By this puzzle based system we will make organized layers of cells.</p>
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<p>But why? Our project will make it possible to individualize the production, to make smaller amounts of products where it is actually needed. </p>
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<p>But why? Our project will make it possible to individualize the production, to make smaller amounts of products where it is actually needed. </p>
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<p>To prevent unlimited expression of the product a molecule is added as a “start button”. The bound puzzle-proteins on the surface make up an enzyme – with the “start button” molecule as a substrate. The molecule is cleaved by the enzyme to a component that starts the individualization of the bacterial layers. In no time the MicroOrgan is formed.</p>
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<p>To prevent unlimited expression of the product a molecule is added as a “start button”. The bound puzzle-proteins on the surface make up an enzyme – with the “start button” molecule as a substrate. The molecule is cleaved by the enzyme to a component that starts the individualization of the bacterial layers. In no time the MicroOrgan is formed.</p>
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Revision as of 14:21, 14 August 2014

UiOslo IGEM 2014

mORGAN

Meet mORGAN, the MicroOrganizer that keeps your project steady.

<iframe width="560" height="315" src="http://www.youtube.com/embed/KHhswxo6xow" frameborder="0" allowfullscreen></iframe>

About the project.

What if we could use bacterial layers as an organ?

What if we could use these bacteria to make small organs of human or environmentally needed products? This is what our project is all about.

We will make distinctive layers of bacteria cells expression different properties of our organ. The bacterial layers will be held together by protein complementation; Different parts of the protein will be expressed on the surface of each bacterial layer. The protein parts work a bit as puzzle pieces – they only stick together when it is a perfect match. By this puzzle based system we will make organized layers of cells.

But why? Our project will make it possible to individualize the production, to make smaller amounts of products where it is actually needed.

<img src="images/Mechanism1.jpg" alt="Sketch.">

<img src="images/Mechanism2.jpg" alt="Sketch.">

To prevent unlimited expression of the product a molecule is added as a “start button”. The bound puzzle-proteins on the surface make up an enzyme – with the “start button” molecule as a substrate. The molecule is cleaved by the enzyme to a component that starts the individualization of the bacterial layers. In no time the MicroOrgan is formed.

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