Team:HZAU-China/Achievements

We apply for a Gold Medal, Best Information Processing Project, Best Model, Best Policy &Practices Project.

As for the Gold Medal

We have met these requirements below:

As for Best Information Processing Project:

Conventional engineered circuits in cells have only a simple regulatory network to process information. Once the environment changed, the approach to handle the information might be invalid. We adopted an elegant means of systems integration to make the cells have adaptability and work well in complex environments. Our engineered cells can process information according to the environment based on rewirable circuits; meanwhile our design overcame some common challenges in Synthetic Biology like host overload and crosstalk.

As for Best Model:

Different from most modeling work in iGEM, we first described the biological processes related to our project rather than list the equations used before directly. In this way, we made sense of the necessary preconditions we needed and it became easier to perform stochastic simulation. Before simulation, we incorporated useful information from wet lab to adjust some parameters and analyzed how some promoter properties would influence our devices. We revealed that the systems behaviors in the repressilator were closely related to the absolute promoter strength of the weakest promoter among the three genes. Many modeling approaches, including deterministic and stochastic simulations, phase analysis, parameter scanning, theoretical inference, were presented in our modeling part. Moreover, we introduced a novel design principle to help other researchers to finish their custom designs.

As for Best Policy & Practices Project：