Team:HZAU-China/Humanities/semiotics

Rediscovering iGEM in the Context of Runic Alphabets

This part could be regarded as a bit of recreational reading.

1. Motivation

Symbols compose of our ideological world. Some are necessities of our daily life, such as characters---symbols of meaning, bills---symbols of money, musical notes---symbols of sound, etc. Symbols are what we give them meaning to, but many things can also be given new meaning back if put into the context of a certain symbol system.

The Elder Futhark is the oldest form of runic language in the Nordic area, it is both a lost language and a mature symbol system with 24 characters. Archaeologists of Scandinavia would be familiar with them, for ancient Norse wrote their tablets and stones under this symbol system. Among the more serious study of this language is the Futhark journal, which is dedicated to the study of runic symbols; however, it has also become a pop culture among a certain group of westerners, and its meanings are no longer a privilege of the well-studied, though much of what they preach still lack sufficient support from the scientific side, and only immeasurable empirical evidence exist. Sadly no one speaks of it in serious places today, so this part is attached to our project as a recreational reading.

Figure 1: The Elder Futhark. Source:http://www.sunnyway.com/runes/meanings.html

Runic language was employed by the ancient Nordic people to write scripts of law, rules, epitaphs, and things of great significance and weight. Though the symbol system was invented by them and given meaning to by them in the first place, they nonetheless believed that using it would bestow new meaning back upon the words they are writing. I found this act interesting, and experimented it on various other places, starting from iGEM, initials of the International Genetically Engineered Machine Competition, curious as to what new meaning it possibly speaks of it that I hadn't realized.

2. Method

The method is fairly simple, just find the four letters equivalent of I, G, E, M in the Elder Futhark, which are Isa, Gebo, Ehwaz, Mannaz. I find these four letters describe the properties of iGEM competition perfectly.

Starting from Isa. Isa means ice, winter, immobility, isolation, but also the same ice that have the possibilities of life hidden under it. Gebo in shape makes one think of the X chromosome, and in meaning it roughly means exchange, a gift given and harmony, sometimes between different genders. Ehwaz stands for horse and loyalty, in the sense a horse is loyal and bonded to his master. Also movement, vehicle, dual advancement. Mannaz stands for mankind, humanity, community, and all their indications.

The four letters perfectly describes the development process of iGEM. If read from left to right as is done by us, the chronological order, we obtain the following sets of interpretation:

2.1 iGEM History

The four letters tell the history of iGEM, and reveals its goal.

i, Isa At the beginning there is ice, under which the tiny spark of synthetic biology dwelled. It symbolised for the general starting environment of iGEM, and implied the would-be continued frozen state or slow development should synthetic biologists insist on working isolated and alone.

G,Gebo Then exchange happened. Biobricks were shared, and Registry was built, teams were formed and were exchanging biobricks. Gebo stands for the iGEM philosophy, standardization and exchange.

E,Ehwaz And it was advancing quickly, the scale of iGEM was expanding.

M,Mannaz Ultimately, iGEM will become a big community, where men from many walks of life will be involved.

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Figure 2. iGEM history, read from left to right

2.2 iGEM Context

The four letters tell the history of iGEM, and reveals its goal.

i, Isa Isa stands for the frozen state and possibilities that life could be. Since it's place is at the beginning and an underlying chronological order is always possible in interpretations like this, it's a starting point. Just say it's the static evolutionary state of organisms before human intervention.

G,Gebo Gebo describes the cut-and-paste method iGEMers employ, and symbolise the exchange of genes between organisms. It's a perfect translation, there isn't another letter in the whole futhark that can describe the deeds of bio-engineers better.

E,Ehwaz Ehwaz is the hopeful result iGEMers strive to achieve, the new biobrick, part, organism. Horse symbolise for the donor organism, ``it's master'' the chassis. Combining dualities, iGEMers hope they can work in harmony, and move along together as a new entity. Also, I found no other letter can better describes the property of the engineered organism like Ehwaz. Ehwaz means binding without sacrifice, a mutual advancement.

M,Mannaz Mannaz symbolise the social and ethical concerns of iGEM, it indicates that iGEM puts its deeds into the context of humanity. It does not want to be ``the blind scientist'', and it cares about the welfare of human, society, and it can be seen from the increasing collaboration of scientists and artists, social scientists, designers, etc, such as the aesthetic workshop iGEM initiated in 2010 which produced a book Synthetic Aesthetics.

3. A Comprehensive Description of Our Project.

The front pattern of our team uniform is composed of the four letters of iGEM, and by drawing them with a bit of mutation in shape, we get a pattern that also describes our project well.In our project we designed rewirable circuits, it's a system that consists of three parts, the input device, the information processing device, and the output device. In the input device we used the recombinase system, in the processing device the main idea is rewiring the gene regulatory relationship of network motifs, and in the output device we utilised different fluorescence to see if the rewiring is successful.

Figure 3. iGEM, Elder Futhark, and our project

Input Device, G "G" is designed to be the input device, drawn as a recombinase. The right side of the enzyme is a natural shape of Kenaz, symbolise the torch, the creative fire, the catalysis of change, it connects the touching point that is at the center of "E" and "M".

Processing Device, E,M "E" and "M" are looked at together, for the processing device will need at least two parts to be. They are designed to be the shape of two four-node network motifs drawn in Uri Alon's book Systems Biology. In our project, our team members noticed the similar structures between motifs, and utilised this similarity to design our rewirable circuits. Notice that the Kenaz shape in the recombinase is at the center of the two motifs, it means that it's the recombinase that catalyze for the transition from one motif to another.

Output Device, I "I" is drawn to be the output device, we draw it to be a shape of bottle that contain the bacterium. Different colors of fluorescence will show different state of the processing device.

We didn't use the shape of Gebo, letter G, in this pattern. Instead we substituted it with C, Kenaz, which is more fit in shape, and fits in better with our project specifically.

4. Discussions

Of course, this method is quite clumsy and flawed if you look at it that way. For many other words can share the same initials. But it's fun, isn't it? Besides, I happened to notice that the Campus Magazine of Art and Literature of Massachusetts Institute of Technology is called RUNES. So perhaps at least there ARE people who would be interested in it.

We also made a careful comparison to make sure the result is not a strain interpretation or far-fetched, that no other four letters could better describe iGEM as these four could. So, although we cannot prove it's right, we can't prove it wrong, either.

But what if iGEM changes its name to International Synthetic Biology Competition? Then its initials would be iSB, with Isa, Sowilo, Berkana, and I wonder what that would be. If so, many iGEM-unique features and flavors would be lost. Other combinations may yield other meanings, but we do think that the name iGEM is the best name for this endeavor we've all been taking on.

Have fun!

Reference

[1] P.J. Caiden. The Metaphysical Power Of The Runes. http://www.selfgrowth.com/articles/the-metaphysical-power-of-the-runes

[2] Runic Physics. Robert Blumetti. http://www.vrilology.org/runic_physics.htm

[3] How to Teach a New Age Class by Throwing Around Meaningless Buzzwords (Humor). http://human-stupidity.com/awareness/new-age

[4] What is runology and where does it stand today? Michael P. Barnes. http://www.khm.uio.no/english/research/publications/7th-symposium-preprints/barnes.pdf

[5] http://www.futhark-journal.com/about/

[6] http://www.sunnyway.com/runes/meanings.html

[7] Semiotics.http://www.semioticsigns.com/

[8] Alun Anderson. Synthetic biology gets reborn as an aesthetic dream. http://www.newscientist.com/article/mg22229660.900-synthetic-biology-gets-reborn-as-an-aesthetic-dream.html#.VD31eXExisg

[9] Alexandra Daisy Ginsberg, Jane Calvert, Pablo Schyfter, Alistair Elfick, Synthetic Aesthetics: Investigating Synthetic Biology's Designs on Nature. http://www.amazon.com/Synthetic-Aesthetics-Investigating-Biologys-Designs/dp/026201999X/ref=sr_1_1?ie=UTF8&qid=1413346901&sr=8-1&keywords=synthetic+aesthetics