Team:Hong Kong HKUST/pneumosensor
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<p class="first_letter_enhanced"><i>Streptococcus pneumoniae</i> is responsible for approximately 1.6 million deaths every year mostly in developing countries where vaccination | <p class="first_letter_enhanced"><i>Streptococcus pneumoniae</i> is responsible for approximately 1.6 million deaths every year mostly in developing countries where vaccination | ||
is unaffordable. To provide an affordable solution to combat pneumococcal diseases, we are engineering an <i>E. coli</i> "Pneumosensor", that will | is unaffordable. To provide an affordable solution to combat pneumococcal diseases, we are engineering an <i>E. coli</i> "Pneumosensor", that will | ||
- | work inside an in vitro diagnostic device. Through this cheaper and easier diagnosis method, people can prepare themselves better against the | + | work inside as an in vitro diagnostic device. Through this cheaper and easier diagnosis method, people can prepare themselves better against the |
transmission and adversity of <i>S. Pneumoniae</i>.</p> | transmission and adversity of <i>S. Pneumoniae</i>.</p> | ||
<p>Pneumosensor has a rewired comCDE signal transduction pathway native to <i>S. pneumoniae</i> that detects | <p>Pneumosensor has a rewired comCDE signal transduction pathway native to <i>S. pneumoniae</i> that detects | ||
autoinducer molecules released specifically by <i>S. pneumoniae</i>. It is also equipped with a new promoter for the specific and tight regulation of | autoinducer molecules released specifically by <i>S. pneumoniae</i>. It is also equipped with a new promoter for the specific and tight regulation of | ||
- | target gene expression in <i>E. coli</i> | + | target gene expression in <i>E. coli</i>. </p> |
- | + | ||
</div> | </div> | ||
</td> | </td> |
Revision as of 06:35, 4 October 2014
Pneumosensor Project Abstract
Streptococcus pneumoniae is responsible for approximately 1.6 million deaths every year mostly in developing countries where vaccination is unaffordable. To provide an affordable solution to combat pneumococcal diseases, we are engineering an E. coli "Pneumosensor", that will work inside as an in vitro diagnostic device. Through this cheaper and easier diagnosis method, people can prepare themselves better against the transmission and adversity of S. Pneumoniae. Pneumosensor has a rewired comCDE signal transduction pathway native to S. pneumoniae that detects autoinducer molecules released specifically by S. pneumoniae. It is also equipped with a new promoter for the specific and tight regulation of target gene expression in E. coli. |
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