Team:UI-Indonesia/Human Practice/SynBio Shout Out

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<h2>About Our Project</h2>
<h2>About Our Project</h2>
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<p>Biofilm is a matrix extracellular polymeric substances (EPS) that is surrounding microbial collonies. It causes more than 65% of all microbial infections. Most of pathogenic bacteria could make biofilm that can cause antibiotic resistance issue and increase its pathogenecity. Our <i>Escherichia coli</i> can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing molecule. Our team will focus in <i>Vibrio cholerae</i> because it is a cause of cholera as a deadly tropical countries disease. We present our <i>E. coli</i> agent that can degrade biofilm of <i>V. cholerae</i> after it can detect quorum sensing molecule from <i>V. cholerae</i>, CAI-1, by CqsS receptor. Then our <i>E. coli</i> agent will activate motility gene, CheZ, to hunt <i>V. cholerae</i>. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and peptide 1018 that will kill <i>V. cholerae</i>.
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Our project can be applied in broad spectrum bacteria. Not only <i>Vibrio cholerae</i> but also other bacteria such as: <i>Pseudomonas aerugoinosa</i>, <i>Bacillus substillis</i>, <i>Klebsiella pneumonia</i>, <i>Staphylococcus aureus</i>, and <i>E. coli</i> Top 10.</p>
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Revision as of 18:40, 17 October 2014

About Our Project

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Retrieved from "http://2014.igem.org/Team:UI-Indonesia/Human_Practice/SynBio_Shout_Out"