Team:TU Eindhoven/Team Supervisors

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<h2>TU Eindhoven iGEM Team 2014</h2>
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        <span>Introduction</span>  
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      <span>Tom de Greef</span>
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      <p class="para">This year’s iGEM team of the Eindhoven University of Technology focuses on a fundamental problem in the application of genetically modified bacteria: bacteria are not suited for many environments.
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      <p class="para">My name is Anke Boschman and I will take on the role of lab captain, meaning I will be responsible for all the exciting experiments we will perform in the wet lab.  Together with Glenn, the modelling captain, I will keep an overview of all the tasks and information and we will schedule and organize the team meetings.  
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For example, local bacterial production of medicine has a promising future as a medical treatment, but the human immune system is still a big limiting factor for this new technology. Another field that would greatly benefit from more resilient bacteria is the bioreactor industry. Bacteria that can survive in high pressure and temperature environments can help increasing efficiency of reactors.
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At the moment, I’m a second year student at the Eindhoven University of Technology. I’m enrolled in the bachelor Biomedical Engineering. I joined this year’s iGEM team because I like to challenge myself and I believed iGEM would be a really nice challenge since it combines the field of synthetic biology with model based engineering. I also liked the fact that you would be able to conduct your own research during a team project. Moreover, I’m curious whether full time lab work would suit me and iGEM seemed like the opportunity to get in touch with this kind of work. I hope that after bringing this iGEM project successfully to an end, I have acquired some nice skills that I’m able to apply often in my future activities. In the future, I hope I will be enjoying executing scientific research – although I do not yet know whether this will be in the field of synthetic biology. </p>
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To create such resilient bacteria the 2014 team has designed a ‘plug and play’ system using copper free click chemistry to attach different chemical groups to create bio-layers on E. Coli cell membranes. Circularly permuted OmpX (CPX), an outer membrane protein, was mutated to contain an azido-functionalized unnatural amino acid. CPX  functions as an anchor for any DBCO functionalized molecule to click onto. The polymers used in this project were designed to form hydrogels, which enables the bacteria to have antifouling properties.
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<a class="btn" href="mailto:a.m.boschman@student.tue.nl">e-mail me</a>
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  <span>Application</span>  
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      <span>Bas Bögels - PR</span>
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      <p class="para">With our team’s biomedical background in mind, an anti-fouling chemical layer for use in the human body was chosen to test the ‘plug and play’ system. An anti-fouling hydrogel has to have little to no interaction with the human immune system, thus preventing immune responses caused by the presence of bacteria. Dibenzocyclooctyne Polyethylene glycol 10kDa (DBCO-PEG 10kDa) was chosen as the molecule to click onto OmpX to form the hydrogel because it has good anti-fouling properties and the modular length allows for easy testing on a smaller scale.</p>
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      <p class="para">My name is Bas Bögels and I’m the team’s jack of all trades, doing lab work but also assisting the modelling team, and doing the external communications.
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I’m currently in the second year of the bachelor Biomedical Engineering at the Eindhoven University of Technology. I joined the iGEM team, because I wanted to work on a large project which wasn’t already done at our university (or elsewhere) and learn to do scientific research and plan your own project. Also I’m using iGEM to determine if the field of synthetic engineering is something I would like to specialize in. After iGEM I hope to have learned how to do my own research and hopefully decided if this field is something I would like to study further.
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  <span>Microfluidics</span>  
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      <span>Boris Arts - Sponsoring</span>
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      <p class="para">In order to precisely control the hydrogel formation, microfluidic devices are used in which the conditions are optimal to form individually encapsulated cells. This way clustering of cells is prevented and the end product will be usable beads instead of large aggregated blobs. </p>
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      <p class="para">My name is Boris Arts and I’m part of the modelling team. Next to my main role, I make sure all expenses will be covered by enlisting sponsors.
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Currently I’m a third year student studying Biomedical Engineering at the Eindhoven University of Technology. I joined the iGEM team to do research in the field of synthetic biology because this is one of my areas of interest. Also I think it is a good way to experience how to build a research from the ground up and to apply everything you learned during the courses to the real world.
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After iGEM I will continue studying in the field of biomedical chemistry and biomaterials, focusing on designing new materials used for tissue engineering and pharmaceuticals.
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      <span>Wiggert Altenburg - Lab Nanny</span>
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      <p class="para">My name is Wiggert Altenburg and I work mainly doing lab work and research.
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I study Medical Sciences and Technology at the Eindhoven University of Technology. I joined the iGEM team because it is a great opportunity and I think it is awesome to fully realize a whole research project while we’re all still students. After iGEM I want to do a Master and PhD in the field of Chemical Biology.
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Latest revision as of 18:32, 30 August 2014

TU Eindhoven iGEM Team

TU Eindhoven iGEM Team 2014

Tom de Greef

My name is Anke Boschman and I will take on the role of lab captain, meaning I will be responsible for all the exciting experiments we will perform in the wet lab. Together with Glenn, the modelling captain, I will keep an overview of all the tasks and information and we will schedule and organize the team meetings. At the moment, I’m a second year student at the Eindhoven University of Technology. I’m enrolled in the bachelor Biomedical Engineering. I joined this year’s iGEM team because I like to challenge myself and I believed iGEM would be a really nice challenge since it combines the field of synthetic biology with model based engineering. I also liked the fact that you would be able to conduct your own research during a team project. Moreover, I’m curious whether full time lab work would suit me and iGEM seemed like the opportunity to get in touch with this kind of work. I hope that after bringing this iGEM project successfully to an end, I have acquired some nice skills that I’m able to apply often in my future activities. In the future, I hope I will be enjoying executing scientific research – although I do not yet know whether this will be in the field of synthetic biology.

e-mail me
Bas Bögels - PR

My name is Bas Bögels and I’m the team’s jack of all trades, doing lab work but also assisting the modelling team, and doing the external communications. I’m currently in the second year of the bachelor Biomedical Engineering at the Eindhoven University of Technology. I joined the iGEM team, because I wanted to work on a large project which wasn’t already done at our university (or elsewhere) and learn to do scientific research and plan your own project. Also I’m using iGEM to determine if the field of synthetic engineering is something I would like to specialize in. After iGEM I hope to have learned how to do my own research and hopefully decided if this field is something I would like to study further.

e-mail me
Boris Arts - Sponsoring

My name is Boris Arts and I’m part of the modelling team. Next to my main role, I make sure all expenses will be covered by enlisting sponsors. Currently I’m a third year student studying Biomedical Engineering at the Eindhoven University of Technology. I joined the iGEM team to do research in the field of synthetic biology because this is one of my areas of interest. Also I think it is a good way to experience how to build a research from the ground up and to apply everything you learned during the courses to the real world. After iGEM I will continue studying in the field of biomedical chemistry and biomaterials, focusing on designing new materials used for tissue engineering and pharmaceuticals.

e-mail me
Wiggert Altenburg - Lab Nanny

My name is Wiggert Altenburg and I work mainly doing lab work and research. I study Medical Sciences and Technology at the Eindhoven University of Technology. I joined the iGEM team because it is a great opportunity and I think it is awesome to fully realize a whole research project while we’re all still students. After iGEM I want to do a Master and PhD in the field of Chemical Biology.

e-mail me

Created by iGEM Team TU Eindhoven 2014

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