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Team:Dundee/Attributions
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<h1>Attributions</h2> | <h1>Attributions</h2> | ||
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| - | We would like to thank all of our instructors and advisors, without whom this project would not have been possible. <b>Professor Tracy Palmer</b>, <b>Dr Fordyce Davidson</b> and <b>Professor Frank Sargent</b> guided the team throughout the duration of the project. Their experience and expertise were crucial to the progression of the project and their support got us through long hours working in the lab. Our advisors; <b>Karim Rafie</b> | + | We would like to thank all of our instructors and advisors, without whom this project would not have been possible. <b>Professor Tracy Palmer</b>, <b>Dr Fordyce Davidson</b> and <b>Professor Frank Sargent</b> guided the team throughout the duration of the project. Their experience and expertise were crucial to the progression of the project and their support got us through long hours working in the lab. Our advisors; <b>Karim Rafie</b>, <b>François Cléon</b>, <b>Avril Smart</b> and <b>Scott McCrimmon</b> worked closely with the team to help us achieve our goals, providing critical advice and feedback throughout. Dundee iGEM 2013 alumni <b>Chris Earl</b> and <b>Nasir Ahmad</b> provided us with indispensable support and advice on all aspects of the project. <b>Richard Owen</b> and <b>Lucia Licandro</b> gave input on the project based on their iGEM experience. |
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| - | We would also like to | + | We would also like to thank all of the members of the <b>Division of Molecular Microbiology</b>, in particular: |
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| - | Our project was aided by the valuable support and advice from Tracy Palmer’s lab. In particular, we thank <b>Professor Tracy Palmer</b> and <b>Dr Grant Buchanan</b> for their advice and assistance with molecular biology techniques and <b>Dr James Chalmers</b> for his input on clinical microbiology associated with | + | Our project was aided by the valuable support and advice from Tracy Palmer’s lab. In particular, we thank <b>Professor Tracy Palmer</b> and <b>Dr Grant Buchanan</b> for their advice and assistance with molecular biology techniques and <b>Dr James Chalmers</b> for his input on clinical microbiology associated with Cystic Fibrosis. |
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| - | We would like to thank Maths PhD students <b>Heather Wallace</b>, <b>Liang Wang</b> and <b>Laoshen Li</b> for their help with the | + | We would like to thank Maths PhD students <b>Heather Wallace</b>, <b>Liang Wang</b> and <b>Laoshen Li</b> for their help with the mathematical modelling. |
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| - | We would also like to extend our thanks to the <b> | + | We would also like to extend our thanks to the <b>Cystic Fibrosis clinical staff</b> based at <b>Ninewells Hospital, Dundee</b>, for their advice regarding clinical aspects of Cystic Fibrosis. |
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Latest revision as of 23:08, 17 October 2014
Attributions
With a Little Help from Our Friends
We would like to thank all of our instructors and advisors, without whom this project would not have been possible. Professor Tracy Palmer, Dr Fordyce Davidson and Professor Frank Sargent guided the team throughout the duration of the project. Their experience and expertise were crucial to the progression of the project and their support got us through long hours working in the lab. Our advisors; Karim Rafie, François Cléon, Avril Smart and Scott McCrimmon worked closely with the team to help us achieve our goals, providing critical advice and feedback throughout. Dundee iGEM 2013 alumni Chris Earl and Nasir Ahmad provided us with indispensable support and advice on all aspects of the project. Richard Owen and Lucia Licandro gave input on the project based on their iGEM experience.
We would also like to thank all of the members of the Division of Molecular Microbiology, in particular:
Frank Sargent Lab
We extend thanks to all of the members of Frank Sargent’s lab. Particularly Professor Frank Sargent and Marilia de Costa. Their advice on the wet team’s work and support with protein work and florescence microscopy was extremely valuable to the team. We would also like to thank them for the equipment and resources supplied by Frank Sargent’s lab.
Tracy Palmer Lab
Our project was aided by the valuable support and advice from Tracy Palmer’s lab. In particular, we thank Professor Tracy Palmer and Dr Grant Buchanan for their advice and assistance with molecular biology techniques and Dr James Chalmers for his input on clinical microbiology associated with Cystic Fibrosis.
Robert Ryan Lab
We would like to extend thanks to Dr Robert Ryan and his lab members including Dr Shi-qi An and Connor Bowen. Their donations of Burkholderia, Xanthomonas and Pseudomonas gDNA and advice regarding bacterial signalling were invaluable to the success of our project.
We would also like to thank:
Dr Sarah Coulthust: for supplying us with Vibrio fischeri for testing our device.
Dr Jackie Heillbron - MMB manager
Louise Fisher - MMB secretary
Anna Vainikka - MMB technician
Dr Nicola Stanley-Wall - Reader of Molecular Microbiology
We would like to thank Maths PhD students Heather Wallace, Liang Wang and Laoshen Li for their help with the mathematical modelling.
Dr Steven Reynolds
We would like to thank Dr Reynolds for his advice in the design of the electronic circuit.
Dr Mike MacDonald
We would like to thank Dr MacDonald for giving his time to talk to us about how medical devices are constructed in industry. Also for the advise about the use of optics.
Our Experts:
CF Patients
A heartfelt thanks goes out to all of the CF patients who inspired and influenced the team and our project in many ways. Below is a list of people who were interviewed, but we would like to thank and acknowledge many others who approached us with enthusiasm and helped shape the project.
David Carter
Robbie Marshall
Jamie Campbell
Rebecca Collins
Grant Grey-Brown
Holly Robb
Ricci Bratt
Robert Harrison
Lucy Clarke
Leanne Dingwall
Emily Howard
Siannon Cuthill
Linda McAllan
Scott Cameron
Chris Walker
Gemma Matheson
Michael Lyall
We would also like to extend our thanks to the Cystic Fibrosis clinical staff based at Ninewells Hospital, Dundee, for their advice regarding clinical aspects of Cystic Fibrosis.
Dr James Chalmers - Respiratory physician at Ninewells Hospital, Dundee
Dr Helen Rodgers - Respiratory physician at Ninewells Hospital, Dundee and Western General Hospital, Edinburgh
Lawrie MacDougall - CF Clinical Nurse Specialist
Gill Brady - CF Clinical Nurse Specialist
Ali Smith - Physiotherapist
Alison Marshall - Dietician
Ash Sinclair - Clinical Psychologist
Brian Cox for publicly supporting the project.
Mark Roughly and Avril Smart for their artwork.
STV, the Courier and the Telegraph for helping us spread our message to the public.
The Cystic Fibrosis (CF) Trust, in particular Mr Ed Owen, Dr Janet Allen, and Mr Oli Rayner for the opportunity to talk at the UK CF 50th anniversary conference.
Mr Drew Photography for conducting a photo shoot with the team.
DNA Sequencing Services for providing us with free DNA sequencing.
Dr Sarah Hussain and Roddy Isles for helping us spread the word of The Lung Ranger.
We would like to thank the University of Dundee College of Life Sciences, Eppendorf and New England Biolabs for their donations of equipment and resources.
We would also like to thank BBSRC, the Wellcome Trust, the Biochemical Society and the Society for General Microbiology who funded stipends for 50% of the team, BBSRC EASTBIO Doctoral Training Partnership who funded one stipend and consumable costs and the University of Dundee and the Wellcome Trust Institutional Strategic Support Fund for funding the remainder of the stipends and our attendance at conferences and the Boston Jamboree.
Finally, we would like to thank the iGEM foundation for organising the iGEM competition.
Welcome to Dundee's 2014 Wiki (Site Information)
Cystic Fibrosis is a genetic disease that results in the accumulation of thick mucus in the epithelial linings of the entire body, particularly the respiratory tract. Over the course of a patient’s life, the mucus-lined lung epithelium becomes repeatedly infected with pathogenic bacteria that stimulate an immune response; leading to inflammation, tissue damage, and ultimately, respiratory failure.
The microflora of the Cystic Fibrosis lung changes over time. In childhood, the major coloniser is Staphylococcus aureus, but as the patient matures other bacterial pathogens infect. The later-dominating pathogens, Pseudomonas aeruginosa and Burkholderia cepacia, are very difficult to eradicate and are associated with chronic decline in lung function. Burkholderia is so infectious that patients have to be isolated from one another, and can be denied lung transplants due to the persistence of this bacterium.
It is important, therefore, for medics to monitor and identify the levels of bacteria within the respiratory tract of a Cystic Fibrosis patient. Currently, patients must provide sputum samples and identification of bacteria takes between 72 hours and 2 weeks, by which point the bacteria can be in an antibiotic resistant state.
The Dundee 2014 iGEM project is focused on designing and testing a device that will rapidly and non-invasively identify the bacteria colonising a Cystic Fibrosis patient. Three biosensors will be developed that recognise external signal molecules produced by key bacteria, all of which are known to be in sputum samples of Cystic Fibrosis patients. A quinolone signal (PQS) is produced by Pseudomonas aeruginosa, a Diffusible Signal Factor (DSF) is produced by Stenotrophomonas maltophilia, an organism that is also associated with Cystic Fibrosis lung infection in adults, and BDSF is a related, but chemically distinct molecule that is produced by Burkholderia cepacia.
By engineering signal recognition and signal transduction proteins from these biological systems the Dundee iGEM team want to produce a portable electronic device that will identify infection outside of the clinic, so that patients do not have to travel great distances, and can be used to help health professionals make informed and rapid decisions on antibiotic treatments.
Read this again by clicking on Site Information in the navigation bar!
Bulletin Board (Policy & Practice)
Come look at the poster explaining how we involved the local and national Cystic Fibrosis community in our project, how we listened to people on the front line of the disease and how they affected our project.
School (Project)
Come in and learn about all the parts that make The Lung Ranger. The lab work that we carried out over the summer is explained here in detail, along with the modelling and implementation.
Library (Log Book)
Read about the experience the team has had over the summer. A week by week description of our work, how we carried out that work and some photos of our time together.
Saloon (iGEM community)
Come on in, take a seat and learn how we have interacted with the larger iGem community. Who the team are, who helped them and how we helped others.
College of Life Sciences
With more than 1100 staff and research students and external funding of around £60 million per year, the College of Life Sciences is one of the largest and most productive research institutes in Europe. This reputation is genuinely global and is reflected in the fact that researchers in our laboratories represent no fewer than 62 different nationalities
Division of Mathematics A small friendly Division which offers a lively and modern programme of study at both undergraduate and postgraduate level.We have research groups in Mathematical Biology, Numerical Analysis and Scientific Computing, Magnetohydrodynamics and Applied Analysis.
School of Computing With research areas in Human Centred Computing, Intelligent Systems, Space Technologies and Theory of Computation, the department has an emphasis on development. Furthermore, this department teaches popular undergraduate programs in Applied Computing and Computing Science.
We are a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. We support the brightest minds in biomedical research and the medical humanities. Our breadth of support includes public engagement, education and the application of research to improve health. We are independent of both political and commercial interests.
