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Team:CityU HK
From 2014.igem.org
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} | } | ||
.btn-custom:hover { | .btn-custom:hover { | ||
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| + | border-bottom: 4px solid #EC8318; | ||
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<li data-target="#carousel-example-generic" data-slide-to="1"></li> | <li data-target="#carousel-example-generic" data-slide-to="1"></li> | ||
<li data-target="#carousel-example-generic" data-slide-to="2"></li> | <li data-target="#carousel-example-generic" data-slide-to="2"></li> | ||
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</ol> | </ol> | ||
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</div> | </div> | ||
<div class="item"> | <div class="item"> | ||
| - | <img src="https://static.igem.org/mediawiki/2014/4/4a/CityU_HK_slide2.png | + | <img src="https://static.igem.org/mediawiki/2014/4/4a/CityU_HK_slide2.png" /> |
<div class="carousel-caption"> | <div class="carousel-caption"> | ||
<a href="https://2014.igem.org/Team:CityU_HK/project/module_fad"><button class="btn btn-custom">FadD & FadL</button></a> | <a href="https://2014.igem.org/Team:CityU_HK/project/module_fad"><button class="btn btn-custom">FadD & FadL</button></a> | ||
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</div> | </div> | ||
</div> | </div> | ||
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| + | <img src="https://static.igem.org/mediawiki/2014/f/f6/CityU_HK_hp_group.JPG" width=100% /> | ||
| + | <div class="carousel-caption"> | ||
| + | <a href="https://2014.igem.org/Team:CityU_HK/TeamMember"><button class="btn btn-custom">Meet the Team</button></a> | ||
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</div> | </div> | ||
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<div class="col-sm-12 col-md-12"> | <div class="col-sm-12 col-md-12"> | ||
<h2>Abstract</h2> | <h2>Abstract</h2> | ||
| - | <p>Obesity has now reached epidemic proportions worldwide, which has serious consequences because obesity is associated with various chronic human diseases such as diabetes, hypertension and cardiovascular diseases. With the aim to protect oneself against obesity and debilitating diseases caused by a high-fat diet, we are using a synthetic biology approach to design an Escherichia coli strain (called Fit Coli) that has an enhanced ability to uptake and convert excess fatty acids from fatty foods into a-linolenic acid (ALA). The strategy is to engineer the fadL and fadD genes along with three desaturase genes to facilitate the uptake of long-chain fatty acids and their biotransformation to ALA by the “Fit Coli” strain. It is predicted that the ALA converted from excess fatty acids by Fit Coli is converted to docosahexaenoic acid (DHA), an omega-3-fatty acid, in the human gut, which is well known to have many positive health benefits.</p> | + | <p><b>Obesity</b> has now reached epidemic proportions worldwide, which has serious consequences because obesity is associated with various chronic human diseases such as diabetes, hypertension and cardiovascular diseases. With the aim to protect oneself against obesity and debilitating diseases caused by a high-fat diet, we are using a synthetic biology approach to design an <i>Escherichia coli</i> strain (called <b><font color=#3cc>Fit. Coli</font></b>) that has an enhanced ability to uptake and convert excess fatty acids from fatty foods into a-linolenic acid (ALA). The strategy is to engineer the <i>fadL</i> and <i>fadD</i> genes along with three desaturase genes to facilitate the uptake of long-chain fatty acids and their biotransformation to ALA by the “Fit. Coli” strain. It is predicted that the ALA converted from excess fatty acids by Fit. Coli is converted to docosahexaenoic acid (DHA), an omega-3-fatty acid, in the human gut, which is well known to have many positive health benefits.</p> |
</div> | </div> | ||
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<a href="http://www.cityu.edu.hk/" target="_blank"><img src="https://static.igem.org/mediawiki/2014/9/9c/CityU_HK_citylogo.png" width="95"></a> | <a href="http://www.cityu.edu.hk/" target="_blank"><img src="https://static.igem.org/mediawiki/2014/9/9c/CityU_HK_citylogo.png" width="95"></a> | ||
<a href="http://www6.cityu.edu.hk/bhdbapp/deptweb/index.html" target="_blank"><img src="https://static.igem.org/mediawiki/2014/9/98/CityU_HK_bchlogo.png" width="80"></a> | <a href="http://www6.cityu.edu.hk/bhdbapp/deptweb/index.html" target="_blank"><img src="https://static.igem.org/mediawiki/2014/9/98/CityU_HK_bchlogo.png" width="80"></a> | ||
| - | + | <img src="https://static.igem.org/mediawiki/2014/b/b1/CityU_HK_Invitrogen.png" width="100"> | |
| - | <img src="https://static.igem.org/mediawiki/2014/ | + | <img src="https://static.igem.org/mediawiki/2014/7/7a/CityU_HK_Neblogocol.png" width="135"> |
| - | <img src="https://static.igem.org/mediawiki/2014/ | + | <img src="https://static.igem.org/mediawiki/2014/d/dc/CityU_HK_IDT-Logo.png" width="125"> |
| + | </div> <!-- end of col-md-7--> | ||
| - | |||
<div class="col-md-5"> | <div class="col-md-5"> | ||
<h3>Stay connected!</h3> | <h3>Stay connected!</h3> | ||
| - | <p>email: <a href=" | + | <p>email: <a href="mailto:cityuhk.igem@gmail.com">cityuhk.igem@gmail.com</a></p> |
| - | <a href=" | + | <a href="http://www.facebook.com/igem.2014CityU"><img src="https://static.igem.org/mediawiki/2014/3/31/CityU_HK_fb_logo.png" width="50" height="48"></a> |
| - | <a href=" | + | <a href="http://twitter.com/CityUHK_iGEM"><img src="http://ibo2014.org/wordpress/wp-content/themes/ibo2014/img/navbar/twitter_icon.png" width="49" height="51"></a> |
| - | <a href=" | + | <a href="http://www.youtube.com/channel/UC0_bUWwafB4m0K6mFdXN7-w"><img src="https://static.igem.org/mediawiki/2014/1/12/CityU_HK_youtube_logo.png" width="52" height="50"></a> |
</div> <!--end of col-md-5--> | </div> <!--end of col-md-5--> | ||
| - | </div> | + | </div> <!-- end of row--> |
<div class="row"> | <div class="row"> | ||
Latest revision as of 00:22, 18 October 2014
Abstract
Obesity has now reached epidemic proportions worldwide, which has serious consequences because obesity is associated with various chronic human diseases such as diabetes, hypertension and cardiovascular diseases. With the aim to protect oneself against obesity and debilitating diseases caused by a high-fat diet, we are using a synthetic biology approach to design an Escherichia coli strain (called Fit. Coli) that has an enhanced ability to uptake and convert excess fatty acids from fatty foods into a-linolenic acid (ALA). The strategy is to engineer the fadL and fadD genes along with three desaturase genes to facilitate the uptake of long-chain fatty acids and their biotransformation to ALA by the “Fit. Coli” strain. It is predicted that the ALA converted from excess fatty acids by Fit. Coli is converted to docosahexaenoic acid (DHA), an omega-3-fatty acid, in the human gut, which is well known to have many positive health benefits.
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