Team:UI-Indonesia

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Latest revision as of 01:54, 18 October 2014

About Our Project

Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our Escherichia coli can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in Vibrio cholerae because it causes cholera, one of the deadly tropical country disease. We present our E. coli that can degrade biofilm of V. cholerae after it detects quorum sensing signal molecule from V. cholerae, CAI-1, by CqsS receptor. Then our E. coli will activate motility gene, CheZ, to hunt V. cholerae. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill V. cholerae.

Our project can be applied in broad application. Not only fighting the Vibrio cholerae but also the other bacteria such as: Pseudomonas aerugoinosa, Bacillus substillis, Klebsiella pneumonia, Staphylococcus aureus, and E. coli Top 10.

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-  <a class="tour start" href="https://2013.igem.org/Team:TU-Munich/Project/Overview">Take the Tour</a>
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-  <a class="button entrepreneur" href="https://2013.igem.org/Team:TU-Munich/Results/Economics">Entrepreneur</a>
-  <a class="button physco" href="https://2013.igem.org/Team:TU-Munich/Project/Physcomitrella">Physco</a>
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-== PhyscoFilter &ndash; Clean different. ==
-The contamination of aquatic ecosystems with a multitude of anthropogenic pollutants has been a problem since the industrial revolution. Antibiotics, hormones and various noxious substances threaten environmental health and are not effectively removed by conventional waste water treatment. We propose to employ transgenic plants which produce effectors for enzymatic degradation ([https://2013.igem.org/Team:TU-Munich/Project/Biodegradation BioDegradation]) or specific binding ([https://2013.igem.org/Team:TU-Munich/Project/Bioaccumulation BioAccumulation]) of pollutants. The autotrophic, sedentary, aquatic nature of the moss [https://2013.igem.org/Team:TU-Munich/Project/Physcomitrella ''Physcomitrella patens''] makes it an optimal chassis for a self-renewing, low-maintenance and cheap water filter. A light-triggered [https://2013.igem.org/Team:TU-Munich/Project/Killswitch kill switch] prevents unintended environmental spreading by limiting viability to places where the spectrum of sunlight is appropriately filtered. Furthermore, we have developed a device to [https://2013.igem.org/Team:TU-Munich/Results/Implementation implement our filter] in an aquatic environment, investigated the application of this new technology and examined its [https://2013.igem.org/Team:TU-Munich/Results/Economics economic feasibility]. Based on our results, the PhyscoFilter may become a game-changing approach to improve global water quality in an affordable and sustainable fashion.
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-== Achievements ==
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-==== European Jamboree [https://igem.org/Results?year=2013&region=All&division=igem results]: ====
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-* Gold medal
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-* Best Wiki
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-* European First Runner Up
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-==== World Jamboree [https://igem.org/Results?year=2013&region=All&division=igem results]: ====
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-* Best Environment Project
-* World First Runner Up
-==== Business plan competitions after iGEM: ====
-* 1<sup>st</sup> place at the [http://www.tum.de/die-tum/aktuelles/pressemitteilungen/kurz/article/31350/ TUM IdeAward]
-* 2<sup>nd</sup> place at the [http://www.presseportal.de/print/2731699-projekt-zum-internet-der-dinge-gewinnt-hochschulwettbewerb-der.html Be.Project Competition]
-* 3<sup>rd</sup> place in the second round of the [http://www.tum.de/wirtschaft/entrepreneurship/entrepreneurship-news/artikel/article/31515/ Munich Business Plan Competition]
-</div>
-== Sponsors ==
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+<h2>About Our Project</h2>
-<a class="sponsor" href="http://www.promega.de/"><img src="https://static.igem.org/mediawiki/2013/f/f0/Promega-300.jpg" width="175px"></a>
+<p>Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our <i>Escherichia coli</i> can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in <i>Vibrio cholerae</i> because it causes cholera, one of the deadly tropical country disease. We present our <i>E. coli</i> that can degrade biofilm of <i>V. cholerae</i> after it detects quorum sensing signal molecule from <i>V. cholerae</i>, CAI-1, by CqsS receptor. Then our <i>E. coli</i> will activate motility gene, CheZ, to hunt <i>V. cholerae</i>. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill <i>V. cholerae</i>.
-<a class="sponsor" href="http://www.qiagen.com/"><img src="https://static.igem.org/mediawiki/2013/6/60/TUM13_Sponsor_Qiagen.png" width="100px"></a>
+<br>
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+<br>
-<a class="sponsor" href="http://eu.idtdna.com/site/"><img src="https://static.igem.org/mediawiki/2013/1/13/Bonn_sponsor_idt.jpg" width="180px"></a>
+Our project can be applied in broad application. Not only fighting the <i>Vibrio cholerae</i> but also the other bacteria such as: <i>Pseudomonas aerugoinosa</i>, <i>Bacillus substillis</i>, <i>Klebsiella pneumonia</i>, <i>Staphylococcus aureus</i>, and <i>E. coli</i> Top 10.</p>
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