Team:Heidelberg

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<a href="https://2014.igem.org" style="position:absolute;z-index:1;"><img src="/wiki/images/5/5d/IGEM_logo_white.png" style="height:70px;" alt="iGEM Logo" /></a>
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<div class="col-lg-6 col-md-6 col-sm-12 impressiv">
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<h3 class="normal-medium-text">iGEM TEAM <span>HEIDELBERG</span> 2014</h3>
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<h1 class="very-large-text">THE RING<br />OF <span>FIRE</span></h1>
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<p style="font-size:30px"> Click <a href="/Team:Heidelberg/Project#Abstract">here</a> to view our abstract.
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<br/>
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Scroll down to EXPLORE our project.
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<p><span class="larger red-text">Nature</span> has made many curious inventions. One of these are</p>
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<h1 class="very-large-text red-text bold" style="text-align:right;"><a href="https://2014.igem.org/Team:Heidelberg/Toolbox/Circularization">CIRCULAR PROTEINS</a></h1>
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<p>which are unconventional peptides that neither have a beginning, nor an ending</p><br>
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<p class="normal-medium-text bold">These proteins are extremely <span class="red-text">resistant</span> against
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<span class="red-text">high temperatures</span>, pH changes and proteases.</p>
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<p class="normal-medium-text align-right">We established protein <a href="/Team:Heidelberg/Toolbox/Circularization"> circularization </a> as a new<br>powerful tool for Synthetic Biology and set the foundations<br>to render any protein heat stable.</p>
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<h1 class="large-text bold">Wondering how we circularize?</h1>
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<h1 >WELCOME TO iGEM 2014 Team Heidelberg! </h1>
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<h2 class="normal-medium-text align-right bold">Let us introduce you to the next generation of bioengineering...</h2>
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<p>Your team has been approved and you are ready to start the iGEM season!
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<h2 class="align-right" style="font-size: 40px; font-weight:normal">come DISCOVER the <a href="/Team:Heidelberg/Project/Background">MECHANISM of SPLIT INTEINS</a></h2><br><br>
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:Heidelberg&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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<p class=""><span class="larger">Inteins excise themselves out of proteins and in doing so the remaining flanking parts are irreversibly joined</span></p>
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<p><span class="larger">–&nbsp;an effective mechanism to circularize proteins.</span></p>
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<p class="normal-medium-text">But messing with protein structure can be disastrous,<br><span class="medium-text">you can only win with good <a class="bold" href="/Team:Heidelberg/Modeling">MODELING</a>.</span></p><br><br>
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<p class="normal-medium-text"><span>Find out the <span class="bold">EXCITING THEORY</span><br>behind <span class="bold">RIGID LINKERS</span> and their <span class="bold">ANGLES</span></span></p>
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<br>
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<p><span class="larger">We developed <a href="/Ream:Heidelberg/Software/Linker_Software">CRAUT</a>,<br>
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a comprehensive software which identifies<br>
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the optimal path to connect a protein’s termini<br>
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preserving structure and function.</span></p>
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<p><span class="larger">Look at our extensive wet-lab SCREENING to improve and calibrate our software using <a class="red-text" href="/Team:Heidelberg/Project/Linker_Screening">lambda lysozyme</a>!</span></p>
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<a href="/Team:Heidelberg/Software/igemathome"><img class="img-responsive" src="/wiki/images/e/e5/Heidelberg_Frontpage_igemathome.png"></a>
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<p class="align-right"><span class="larger">As calculations on protein structures are costly<br>we involved the rest of the world with</span></p>
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<h1 class="align-right bold very-large-text dark-red-text"><span style="font-size:1.5em;"><a href="/Team:Heidelberg/Human_Practice/igemathome">iGEM@home</a></span></h1>
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<h3 class="medium-text bold">Empowering science!</h3><br>
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<p class="normal-medium-text"><a href="/Team:Heidelberg/Software/igemathome">NEW PLATFORM</a> for distributed computing.</p>
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<p><span class="larger">Volunteers provide the idle calacity of their home computers.</span></p>
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<p class=""><span class="larger">And, with an established user base with more than <span class="larger red-text">1000</span> computers, we effectively <a href="/Team:Heidelberg/Human_Practice/igemathome" >bring synthetic biology to society</a> in a new way!</span></p>
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<a href="/Team:Heidelberg/Human_Practice/igemathome" ><img style="position:relative; top: -35px;" class="img-responsive" src="/wiki/images/5/52/Heidelberg_Frontpage_igemathome_cloud.png"></a>
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<a href="/Team:Heidelberg/Project/PCR_2.0" ><img class="img-responsive" src="/wiki/images/a/a6/Heidelberg_Project_Dnmt1.png"></a>
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<h1 class="large-text">Our Application:</h1>
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<h1 class="dark-grey-text large-text" style="text-align: right;"><span class="medium-large-text">circular <a href="/Team:Heidelberg/Project/PCR_2.0">heat-stable</a></span><br>DNA-methyltransferase</h1>
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<br><br><p><span class="larger">Wouldn´t it be great to amplify DNA preserving the encoded epigenetic information?</span></p>
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<p><span class="larger">This could lead to an ENTIRELY NEW way of performing PCRs with a <a href="/Team:Heidelberg/Project/PCR_2.0">heat stable methyltransferase</a>!</span></p>
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<p>&nbsp;<br /><span class="larger">We'd like to call it</span></p>
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<a href="/Team:Heidelberg/Project/PCR_2.0" class="title-dnmt1">PCR 2.0</a>
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<a href="https://2014.igem.org/Team:Heidelberg/Project/Toolbox#Circularization">
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<img src="/wiki/images/5/58/Heidelberg_Toolbox_Circularization.png" id="circ-icon" class="toolbox-icon">&nbsp;&nbsp;CIRCULARIZATION
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<a href="https://2014.igem.org/Team:Heidelberg/Project/Toolbox#Oligomerization">
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<img src="/wiki/images/4/40/Oligomerization.png" id="oligo-icon" class="toolbox-icon">&nbsp;&nbsp;OLIGOMERIZATION
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<a href="https://2014.igem.org/Team:Heidelberg/Project/Toolbox#Fusion_and_Tagging">
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<img src="/wiki/images/8/87/Heidelberg_Toolbox_Fusion.png" id="fusion-icon" class="toolbox-icon">&nbsp;&nbsp;FUSION
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<a href="https://2014.igem.org/Team:Heidelberg/Project/Toolbox#On_Off">
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<img src="/wiki/images/c/c2/Heidelberg_Toolbox_On-Off.png" id="onoff-icon" class="toolbox-icon">&nbsp;&nbsp;ON/OFF
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<img src="/wiki/images/0/04/Heidelberg_Toolbox_Purification.png" id="purification-icon" class="toolbox-icon">&nbsp;&nbsp;PURIFICATION
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<h2 class="normal-medium-text align-right">One more thing.<br>Inteins are capable of much more!</h2>
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<h1 class="medium-large-text align-right bold">We show you the world of</h1>
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<h1 class="medium-text align-right red-text bold" style="font-size: 41px;">post-translational MODIFICATIONS</h1><br><br>
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<p class="align-right "><span class="larger">We created an <a href="/Team:Heidelberg/Project/Toolbox">INTEIN TOOLBOX</a> so you can easily modify your protein in a standardized way.</span></p>
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<p class="align-right"><span class="larger">Take a look at our <a href="/Team:Heidelberg/Parts/RFC">RFC</a>!</span></p>
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<p class="align-right"><span class="larger">Explore all our tools!</span></p>
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<h1>Who are we?</h1>
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<p>We are the iGEM Team Heidelberg 2014 consisting of 12 highly motivated bachelor and master students studying at Heidelberg University.</p>
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<p>For our project we got great feedback and support from our supervisors.</p>
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<p>Take a look at our <a href="/Team:Heidelberg/Team">Teampage</a>!</p>
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<h1>Thank you!</h1>
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<p>We want thank all people who helped us and supported our work in the lab.</p>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=Heidelberg"style="color:#000000"> Official Team Profile </a></td>
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<li><a href="https://2014.igem.org/Team:Heidelberg">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:Heidelberg/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=Heidelberg">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:Heidelberg/Project">Project</a> </li>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:SYSU-China">2013 SYSU China</a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<li> <a href="https://2013.igem.org/Team:Lethbridge">2013 Lethbridge</a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<td> </td>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and what you plan to do.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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<li>Have lots of fun! </li>
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Latest revision as of 23:43, 16 October 2014

iGEM Logo
Ring of fire Image

iGEM TEAM HEIDELBERG 2014

THE RING
OF FIRE

Click here to view our abstract.
Scroll down to EXPLORE our project.

Nature has made many curious inventions. One of these are

CIRCULAR PROTEINS

which are unconventional peptides that neither have a beginning, nor an ending


These proteins are extremely resistant against high temperatures, pH changes and proteases.

We established protein circularization as a new
powerful tool for Synthetic Biology and set the foundations
to render any protein heat stable.

Wondering how we circularize?

Let us introduce you to the next generation of bioengineering...

come DISCOVER the MECHANISM of SPLIT INTEINS



Inteins excise themselves out of proteins and in doing so the remaining flanking parts are irreversibly joined

– an effective mechanism to circularize proteins.

But messing with protein structure can be disastrous,
you can only win with good MODELING.



Find out the EXCITING THEORY
behind RIGID LINKERS and their ANGLES


We developed CRAUT,
a comprehensive software which identifies
the optimal path to connect a protein’s termini
preserving structure and function.

Look at our extensive wet-lab SCREENING to improve and calibrate our software using lambda lysozyme!

As calculations on protein structures are costly
we involved the rest of the world with

iGEM@home

Empowering science!


NEW PLATFORM for distributed computing.

Volunteers provide the idle calacity of their home computers.

And, with an established user base with more than 1000 computers, we effectively bring synthetic biology to society in a new way!

Our Application:

circular heat-stable
DNA-methyltransferase



Wouldn´t it be great to amplify DNA preserving the encoded epigenetic information?

This could lead to an ENTIRELY NEW way of performing PCRs with a heat stable methyltransferase!

 
We'd like to call it

One more thing.
Inteins are capable of much more!

We show you the world of

post-translational MODIFICATIONS



We created an INTEIN TOOLBOX so you can easily modify your protein in a standardized way.

Take a look at our RFC!

Explore all our tools!

Who are we?

We are the iGEM Team Heidelberg 2014 consisting of 12 highly motivated bachelor and master students studying at Heidelberg University.

For our project we got great feedback and support from our supervisors.

Take a look at our Teampage!

Thank you!

We want thank all people who helped us and supported our work in the lab.

Retrieved from "http://2014.igem.org/Team:Heidelberg"