iGEM TEAM HEIDELBERG 2014
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Nature has made many curious inventions. One of these are
which are unconventional peptides that neither have a beginning, nor an ending
These proteins are extremely resistant against high temperatures, pH changes and proteases.
We established protein circularization as a new
powerful tool for Synthetic Biology and set the foundations
to render any protein heat stable.
Wondering how we circularize?
Let us introduce you to the next generation of bioengineering...
come DISCOVER the MECHANISM of SPLIT INTEINS
Inteins excise themselves out of proteins and in doing so the remaining flanking parts are irreversibly joined
– an effective mechanism to circularize proteins.
But messing with protein structure can be disastrous,
you can only win with good MODELING.
Find out the EXCITING THEORY
behind RIGID LINKERS and their ANGLES
We developed CRAUT,
a comprehensive software which identifies
the optimal path to connect a protein’s termini
preserving structure and function.
Look at our extensive wet-lab SCREENING to improve and calibrate our software using lambda lysozyme!
As calculations on protein structures are costly
we involved the rest of the world with
NEW PLATFORM for distributed computing.
Volunteers provide the idle calacity of their home computers.
And, with an established user base with more than 1000 computers, we effectively bring synthetic biology to society in a new way!
Who are we?
We are the iGEM Team Heidelberg 2014 consisting of 12 highly motivated bachelor and master students studying at Heidelberg University.
For our project we got great feedback and support from our supervisors.
Take a look at our Teampage!
We want thank all people who helped us and supported our work in the lab.