Team:TU Eindhoven/Project/Synergene

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<h2>Project Description</h2>
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<h2>Synergene</h2>
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        <span>Introduction</span>  
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        <span>Scenarios</span>
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      <p class="para">This year’s iGEM team of the Eindhoven University of Technology focuses on a fundamental problem in the application of genetically modified bacteria: bacteria are not suited for many environments.
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      <p class="para">Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus. Vivamus elementum semper nisi. Aenean vulputate eleifend tellus. Aenean leo ligula, porttitor eu, consequat vitae, eleifend ac, enim. Aliquam lorem ante, dapibus in, viverra quis, feugiat a, tellus. Phasellus viverra nulla ut metus varius laoreet. Quisque rutrum. Aenean imperdiet. Etiam ultricies nisi vel augue. Curabitur ullamcorper ultricies nisi. Nam eget dui.
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For example, local bacterial production of medicine has a promising future as a medical treatment, but the human immune system is still a big limiting factor for this new technology. Another field that would greatly benefit from more resilient bacteria is the bioreactor industry. Bacteria that can survive in high pressure and temperature environments can help increasing efficiency of reactors.
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To create such resilient bacteria the 2014 team has designed a ‘plug and play’ system using copper free click chemistry to attach different chemical groups to create bio-layers on E. Coli cell membranes. Circularly permuted OmpX (CPX), an outer membrane protein, was mutated to contain an azido-functionalized unnatural amino acid. CPX  functions as an anchor for any DBCO functionalized molecule to click onto. The polymers used in this project were designed to form hydrogels, which enables the bacteria to have antifouling properties.
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  <span>Application</span>   
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        Scenario 1: <a href="https://2014.igem.org/Team:TU_Eindhoven/Project/Synergene/Scenario1">Oil Eating Bacteria Arrays</a>  
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      <p class="para">With our team’s biomedical background in mind, an anti-fouling chemical layer for use in the human body was chosen to test the ‘plug and play’ system. An anti-fouling hydrogel has to have little to no interaction with the human immune system, thus preventing immune responses caused by the presence of bacteria. Dibenzocyclooctyne Polyethylene glycol 10kDa (DBCO-PEG 10kDa) was chosen as the molecule to click onto OmpX to form the hydrogel because it has good anti-fouling properties and the modular length allows for easy testing on a smaller scale.</p>
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                Scenario 2: <a href="https://2014.igem.org/Team:TU_Eindhoven/Project/Synergene/Scenario2">Bacterial 'Islets of Langerhans'</a>
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                Scenario 3: <a href="https://2014.igem.org/Team:TU_Eindhoven/Project/Synergene/Scenario3">Desalination Bacteria</a>
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Latest revision as of 13:25, 12 September 2014

Synergene

Synergene

Scenarios

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus. Vivamus elementum semper nisi. Aenean vulputate eleifend tellus. Aenean leo ligula, porttitor eu, consequat vitae, eleifend ac, enim. Aliquam lorem ante, dapibus in, viverra quis, feugiat a, tellus. Phasellus viverra nulla ut metus varius laoreet. Quisque rutrum. Aenean imperdiet. Etiam ultricies nisi vel augue. Curabitur ullamcorper ultricies nisi. Nam eget dui.



Scenario 1: Oil Eating Bacteria Arrays

Scenario 2: Bacterial 'Islets of Langerhans'

Scenario 3: Desalination Bacteria


Created by iGEM Team TU Eindhoven 2014

Retrieved from "http://2014.igem.org/Team:TU_Eindhoven/Project/Synergene"