Team:HZAU-China

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         <h2>Project Description<h2>
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         <p>Cells sense the environment, process information, and make response to stimuli. To make cells work well in complex natural environments, lots of processes have to be preset to react to various signals. However, when well-characterized modules are combined to construct higher order systems, unpredictable behaviors often occur because of the interplay between modules. Another significant problem is that complex integrated systems composed of numerous parts may cause cell overload.</p>
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        <p>We propose an elegant method to design higher order systems. Instead of merely combining different functional modules, we construct one integrated processing module with fewer parts by utilizing the common structures between modules. The circuit we designed is a rewirable one and the topological structure of the processing module can be altered to adapt to environmental change. The basic idea is to rewire the connections between parts and devices to implement multiple functions with the help of the site-specific recombination systems.</p>
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         <p>Based on the design principle we put forward, we built two circuits to verify our idea. Each circuit has three modules including an input module, a processing module, and an output module. The input module receives environmental signal and triggers the rewiring of the processing module. The output module monitors real-time processes using fluorescence intensity.</p>
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         <p>Our design approach may lead to a revolutionary step towards system integration in synthetic biology. Potential fields of application include organism development, living therapeutics and environment improvement.</p>
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                <h1>Integration by rewiring!</h1>
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                <p>If the synthetic circuits can be rewired, we will be able to reuse the existing modules to implement another function. In our project, we alter the topological structure of regulatory pathway to process information according to the environmental change.</p>
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                <h3 style="padding-left:20px;"> Balance of biology and engineering!</h3>
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                <p>Modules in engineering are always independent while modules in biology are overlapping and closely related. Our integrated module is simplified as the biological module and independent as the engineering module. It can perform different function at different time. </p>
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                <h1>Super Transformer!</h1>
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                <p>As the development of synthetic biology, we believe our rewirable curcuits will significantly contribute to creating smart biological information processing systems. One day the cells we create will not only serve as cars to bring convenience to life, but also serve as Autobots to save the world.</p>
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    <h5>Background &raquo;</h5>
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<p class="firsttext">When combining parts and modules to create larger scale systems, crosstalk and host overload often get in the way. In our project, we propose an elegant method to implement system integration. </p>
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    <h5>Wetlab &raquo;</h5>
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<p class="firsttext">To realize our idea of rewirable circuit, we should conduct experiments to construct circuits, verify assumptions and test our devices to see if they work as expected.</p>
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  <h5>Modeling &raquo;</h5>
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<p class="firsttext">Mathematic model not only has its application in the prediction and analysis of phenomena, but also contributes to the design of genetic circuits. We hope our model can prove to be insightful and of reference value to other circuit designers.</p>
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    <h5>Outreach &raquo;</h5>
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<p class="firsttext">We devote ourselves to the enhancement of iGEM community. Besides many forms of collaboration, this year we tried to understand it in another way: Humanities and Social Sciences.
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                    <h5>Are you interested in our project and hurrying to see our achievements?</h5>
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                    <p class="highlighttext" style="color: #979797;">We apply for a Gold Medal, Best Information Processing Project, Best Model, Best Policy &Practices Project.</p>
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</br>
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                    <a href="https://2014.igem.org/Team:HZAU-China/Achievements" class="button large gray ">Achievements</a>
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            <p class="copyright-text">&copy; 2014 Huazhong Agricultural University iGEM Team. All rights reserved.</p>
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    <h5>Contacts</h5>
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            <li class="address-icon">No.1, Shizishan Street, Hongshan District<br />Wuhan, Hubei Province,<br />430070, P.R.China</li>
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            <li class="email-icon">Email : hzauigem@gmail.com</li>         
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<li class="twitter-icon">Twitter : hzau_igem</li>
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<li class="wechat-icon">Wechat : hzauigem</li>
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<li class="qq-icon">QQ Group : 313297095</li>
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                <li class="y-icon">YouTube : hzauigem</li>
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Latest revision as of 08:54, 14 May 2015

<!DOCTYPE html> 2014HZAU-China

Integration by rewiring!

If the synthetic circuits can be rewired, we will be able to reuse the existing modules to implement another function. In our project, we alter the topological structure of regulatory pathway to process information according to the environmental change.

Balance of biology and engineering!

Modules in engineering are always independent while modules in biology are overlapping and closely related. Our integrated module is simplified as the biological module and independent as the engineering module. It can perform different function at different time.

Super Transformer!

As the development of synthetic biology, we believe our rewirable curcuits will significantly contribute to creating smart biological information processing systems. One day the cells we create will not only serve as cars to bring convenience to life, but also serve as Autobots to save the world.

Background »

When combining parts and modules to create larger scale systems, crosstalk and host overload often get in the way. In our project, we propose an elegant method to implement system integration.


Wetlab »

To realize our idea of rewirable circuit, we should conduct experiments to construct circuits, verify assumptions and test our devices to see if they work as expected.

Modeling »

Mathematic model not only has its application in the prediction and analysis of phenomena, but also contributes to the design of genetic circuits. We hope our model can prove to be insightful and of reference value to other circuit designers.


Outreach »

We devote ourselves to the enhancement of iGEM community. Besides many forms of collaboration, this year we tried to understand it in another way: Humanities and Social Sciences.

Are you interested in our project and hurrying to see our achievements?

We apply for a Gold Medal, Best Information Processing Project, Best Model, Best Policy &Practices Project.


Achievements

© 2014 Huazhong Agricultural University iGEM Team. All rights reserved.

Contacts
  • No.1, Shizishan Street, Hongshan District
    Wuhan, Hubei Province,
    430070, P.R.China
  • Wechat : hzauigem
  • QQ Group : 313297095
  • YouTube : hzauigem

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