Team:UI-Indonesia

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<li><img src="https://static.igem.org/mediawiki/2014/a/af/UI-Indonesia_Image_MI-Header.png" /></li>
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<h1 >WELCOME TO iGEM 2014! </h1>
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<li><img src="https://static.igem.org/mediawiki/2014/9/9c/UI-Indonesia_Image_SlideLab.jpg" /></li>
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<p>Your team has been approved and you are ready to start the iGEM season!
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        <li><img src="https://static.igem.org/mediawiki/2014/1/15/UI-Indonesia_Image_SliderHP.jpg" /></li>
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<br>On this page you can document your project, introduce your team members, document your progress <br> and share your iGEM experience with the rest of the world! </p>
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        <li><img src="https://static.igem.org/mediawiki/2014/7/7f/UI-Indonesia_Image_SliderTeam.jpg" /></li>
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<h2>About Our Project</h2>
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<p>Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our <i>Escherichia coli</i> can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in <i>Vibrio cholerae</i> because it causes cholera, one of the deadly tropical country disease. We present our <i>E. coli</i> that can degrade biofilm of <i>V. cholerae</i> after it detects quorum sensing signal molecule from <i>V. cholerae</i>, CAI-1, by CqsS receptor. Then our <i>E. coli</i> will activate motility gene, CheZ, to hunt <i>V. cholerae</i>. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill <i>V. cholerae</i>.
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<p style="color:#E7E7E7"> <a href="https://2014.igem.org/wiki/index.php?title=Team:UI-Indonesia&action=edit"style="color:#FFFFFF"> Click here  to edit this page!</a> </p>
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Our project can be applied in broad application. Not only fighting the <i>Vibrio cholerae</i> but also the other bacteria such as: <i>Pseudomonas aerugoinosa</i>, <i>Bacillus substillis</i>, <i>Klebsiella pneumonia</i>, <i>Staphylococcus aureus</i>, and <i>E. coli</i> Top 10.</p>
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<a href="https://2014.igem.org/Team:UI-Indonesia"style="color:#000000">Home </a> </td>
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<a href="https://2014.igem.org/Team:UI-Indonesia/Team"style="color:#000000"> Team </a> </td>
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<a href="https://igem.org/Team.cgi?year=2014&team_name=UI-Indonesia"style="color:#000000"> Official Team Profile </a></td>
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<p> Please be sure to keep these links, your audience will want to find your: </p>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia">Home</a> </li>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia/Team">Team</a> </li>
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<li><a href="https://igem.org/Team.cgi?year=2013&team_name=UI-Indonesia">Official Team Profile</a> </li>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia/Project">Project</a> </li>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia/Parts">Parts</a> </li>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia/Modeling">Modeling</a> </li>
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<li><a href="https://2014.igem.org/Team:UI-Indonesia/Safety">Safety</a> </li>
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<li>As part of your documentation, keep the links from the menu to the left. </li>
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<li>The <a href="https://static.igem.org/mediawiki/igem.org/6/60/Igemlogo_300px.png"> iGEM logo </a> should be placed on the upper part of every page and should link to <a href="https://2014.igem.org/Main_Page">2014.igem.org</a>.</li>
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<p>We are currently working on providing teams with some easy to use design templates.
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<br> In the meantime you can also view other team wikis for inspiration! Here are some very good examples</p>
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<li> <a href="https://2013.igem.org/Team:SDU-Denmark/"> 2013 SDU Denmark </a> </li>
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<li> <a href="https://2013.igem.org/Team:Shenzhen_BGIC_ATCG"> 2013 Shenxhen BGIG ATCG </a></li>
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<li> <a href="https://2013.igem.org/Team:Colombia_Uniandes">2013 Colombia Unianades </a></li>
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<p>For a full wiki list, you can visit <a href="https://igem.org/Team_Wikis?year=2013">iGEM 2013 web sites </a> and <a href="https://igem.org/Team_Wikis?year=2012">iGEM 2012 web sites</a>  lists. </p>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="">iGEM 2013 calendar</a> </li>
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Latest revision as of 01:54, 18 October 2014

About Our Project

Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our Escherichia coli can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in Vibrio cholerae because it causes cholera, one of the deadly tropical country disease. We present our E. coli that can degrade biofilm of V. cholerae after it detects quorum sensing signal molecule from V. cholerae, CAI-1, by CqsS receptor. Then our E. coli will activate motility gene, CheZ, to hunt V. cholerae. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill V. cholerae.

Our project can be applied in broad application. Not only fighting the Vibrio cholerae but also the other bacteria such as: Pseudomonas aerugoinosa, Bacillus substillis, Klebsiella pneumonia, Staphylococcus aureus, and E. coli Top 10.

Retrieved from "http://2014.igem.org/Team:UI-Indonesia"