Team:UI-Indonesia

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<!-- Scripts --> <!--- Thank you to TU-Munich 2013 IGEM Team!! :) -->
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<li><img src="https://static.igem.org/mediawiki/2014/7/76/UI-Indonesia_Image_Slider1.jpg" /></li>
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<li><img src="https://static.igem.org/mediawiki/2014/a/af/UI-Indonesia_Image_MI-Header.png" /></li>
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<h2>Project Overview</h2>
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<h2>About Our Project</h2>
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<p>Biofilm is a matrix extracellular polymeric substances (EPS) that is surrounding microbial collonies. It causes more than 65% of all microbial infections. Most of pathogenic bacteria could make biofilm that can cause antibiotic resistance issue and increase its pathogenecity. Our Escherichia coli can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing molecule. Our team will focus in Vibrio cholerae because it is a cause of cholera as a deadly tropical countries disease. We present our E. coli agent that can degrade biofilm of V. cholerae after it can detect quorum sensing molecule from V. cholerae, CAI-1, by CqsS receptor. Then our E. coli agent will activate motility gene, CheZ, to hunt V. cholerae. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and peptide 1018 that will kill V. cholerae. </p>
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<p>Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our <i>Escherichia coli</i> can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in <i>Vibrio cholerae</i> because it causes cholera, one of the deadly tropical country disease. We present our <i>E. coli</i> that can degrade biofilm of <i>V. cholerae</i> after it detects quorum sensing signal molecule from <i>V. cholerae</i>, CAI-1, by CqsS receptor. Then our <i>E. coli</i> will activate motility gene, CheZ, to hunt <i>V. cholerae</i>. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill <i>V. cholerae</i>.
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Our project can be applied in broad application. Not only fighting the <i>Vibrio cholerae</i> but also the other bacteria such as: <i>Pseudomonas aerugoinosa</i>, <i>Bacillus substillis</i>, <i>Klebsiella pneumonia</i>, <i>Staphylococcus aureus</i>, and <i>E. coli</i> Top 10.</p>
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<h2>Our Project</h2>
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<p>Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit litterarum formas humanitatis per seacula quarta decima et quinta decima. Eodem modo typi, qui nunc nobis videntur parum clari, fiant sollemnes in futurum.</p>
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Latest revision as of 01:54, 18 October 2014

About Our Project

Biofilm is a matrix extracellular polymeric substances (EPS) that surrounds microbial colonies and causes more than 65% microbial infections. Most of the pathogenic bacteria could make biofilm that increases their antibiotic resistance and increase its pathogenecity. Our Escherichia coli can degrade biofilm from various bacteria after it seeks them by detecting their quorum sensing signal molecule. Our team focuses in Vibrio cholerae because it causes cholera, one of the deadly tropical country disease. We present our E. coli that can degrade biofilm of V. cholerae after it detects quorum sensing signal molecule from V. cholerae, CAI-1, by CqsS receptor. Then our E. coli will activate motility gene, CheZ, to hunt V. cholerae. When it arrives, our bacteria will degrade the biofilm by secreting enzymes, such as α-amylase, nuclease, and substilisin to break down the matrix and finally secretes peptide 1018 that will kill V. cholerae.

Our project can be applied in broad application. Not only fighting the Vibrio cholerae but also the other bacteria such as: Pseudomonas aerugoinosa, Bacillus substillis, Klebsiella pneumonia, Staphylococcus aureus, and E. coli Top 10.

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