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Team:UI-Indonesia/Project/Biofilm Degrading
From 2014.igem.org
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Revision as of 00:03, 18 October 2014
Background
Biofilms are dense packaged microbial cells grow on surface or inert and sorround themselves with secreted polymers. Microbial infection estimated 60-80% of microbial infection in the body. According to National Instutute of Health, more than 65% of all microbial infection caused by biofilms[1]. National Institute of Allergy and Infectious Diseases estimates two million healthcare-associated infections (HAIs), most of which associated with biofilms, happened in the United States annually, approximately 100,000 death[2].
Bacteria inside the biofilm is equipped with high resistance towards antibiotics and host immune defenses. In fact, the biofilm is immune towards acid so that it can protect the bacteria from stomach acid. When ignored, the existence of this biofilm can cause severe illness and worsen diarrhea, thus we need specific and effective management. High dose of antibiotic can be an alternative way but higher dose of antibiotic has been given for case with broad resistant , it is not the right answer to fight biofilm. Excessive dose of antibiotic will increase the probability of resistant bacteria[3].
