Team:Valencia Biocampus/Modeling temp2

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= Modeling =
= Modeling =
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    The modelling sub-team aims to predict the main features of our project to understand how stable, standard and orthogonal engineered systems are. In order
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    to accomplish this goal, two different approaches have been taken into account: mRNA and protein expression levels prediction tools and plasmid dynamics.
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    These two approaches may give insight of the presented problem.<u></u><u></u>
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                    <!-- <h2>Welcome to IGHALO!<sup>™</sup></h2>-->
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    In order to predict accurately the mRNA and protein expression levels, we propose a model considering both intrinsic (metabolic burden) and extrinsic (pH
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    or temperature) characteristics of our system. Using this model, we aim to describe the bacterial response to different kind of stresses (<em>e.g.</em>
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    temperature, pH, UV radiation).<u></u><u></u>
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    A second approach tries to predict the behaviour of two different plasmids sharing the same origin of replication in a single cell. As they share the same
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    mechanism of regulation, they may behave in a non-orthogonal way. The model is based in stochastic dynamics (how perturbations may become a relevant
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    feature of the system) using both simulation and analysis tools.<u></u><u></u>
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    While both models are different, we want to create a framework to gain knowledge in engineered molecular biological systems, explaining our experimental
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     results and proposing new hypothesis, to design more reliable and predictable biological machines.
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Revision as of 15:34, 29 September 2014

Modeling

Welcome to Bootsnipp™ ♥

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start using bootsnipp

Create a Bootsnipp™ Profile

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create your profile

Bootsnipp goodies

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start using bootsnipp

Drop comments!

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thanks for staying tuned! ♥ Bootstrap

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