Team:Warwick/Parts/Aptazyme

An aptazyme is an allosteric ribozyme acting as a regulatory riboswitch. It self-splices in response to theophylline, a drug used to treat asthma and other chronic obstructive pulmonary diseases acting as a bronchodilator. This differs from caffeine by one methyl group and a nitrogen atom creating the structure seen below. This is not endogenous to the body therefore we used this element as a "kill switch" for our system.

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              <h1> APTAZYME </h1> <br> <br>-->
 <h2> Click <a href="https://2014.igem.org/Team:Warwick/Parts">here</a> to learn about our Aptazyme. </h2>
-<p> Our modelling in this project has several aims: </p>
+<p>An aptazyme is an allosteric ribozyme acting as a regulatory riboswitch. It self-splices in response to theophylline, a drug used to treat asthma and other chronic obstructive pulmonary diseases acting as a bronchodilator. This differs from caffeine by one methyl group and a nitrogen atom creating the structure seen below. This is not endogenous to the body therefore we used this element as a "kill switch" for our system.</p>
-<ul type="circle">
- <li>To find the amount of DPP-IV reduction reached when the system reaches equilibrium</li>
- <li>To find a way to control the level of DPP-IV reduction</li>
- <li>To find the minimum number of RdRps, replicons, etc to be initially transfected into the cell, which are required to achieve a steady state for the system</li>
- <li>To find out how long does it take for the system to reach equilibrium</li>
- <li>To find out the level of reduction we need to treat diabetes</li>
- <li>To find out how stable the system is (i.e. will the system only work in very specific situations, or in lots of different systems?)
-</ul>