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Team:UCL/Project/Xenobiology
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<p class="edText1"> The wide use of genetically modified organisms causes concerns on how they will interact in the natural environment. In particular could the genetically modiefied microbes escape our constrains, and outcompete the organisms found in the natural ecosystem? Could the DNA we inserted into a specific bacteria be transmitted, with unknown spread of information? </p> | <p class="edText1"> The wide use of genetically modified organisms causes concerns on how they will interact in the natural environment. In particular could the genetically modiefied microbes escape our constrains, and outcompete the organisms found in the natural ecosystem? Could the DNA we inserted into a specific bacteria be transmitted, with unknown spread of information? </p> | ||
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<li>Schmidt, M (2010). Xenobiology: A new form of life as the ultimate biosafety tool <em>Bioessays</em>, <strong>32</strong>, 322-331. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909387/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909387/ </a></li> | <li>Schmidt, M (2010). Xenobiology: A new form of life as the ultimate biosafety tool <em>Bioessays</em>, <strong>32</strong>, 322-331. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909387/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909387/ </a></li> | ||
<li>Malyshev, D.A., Dhami, K., Lavergne, T. et al. (2014). A semi-synthetic organism with an expanded genetic alphabet <em>Nature</em>, <strong>509</strong>, 385-388. <a href="http://www.nature.com/nature/journal/v509/n7500/full/nature13314.html">http://www.nature.com/nature/journal/v509/n7500/full/nature13314.html </a></li> | <li>Malyshev, D.A., Dhami, K., Lavergne, T. et al. (2014). A semi-synthetic organism with an expanded genetic alphabet <em>Nature</em>, <strong>509</strong>, 385-388. <a href="http://www.nature.com/nature/journal/v509/n7500/full/nature13314.html">http://www.nature.com/nature/journal/v509/n7500/full/nature13314.html </a></li> | ||
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Revision as of 16:46, 17 September 2014
The ultimate biosafety tool
See paper, emails in which you explained it and diary. write as google doc than transfer here. passionate and let proofread
Biosafety in Synthetic Biology
The wide use of genetically modified organisms causes concerns on how they will interact in the natural environment. In particular could the genetically modiefied microbes escape our constrains, and outcompete the organisms found in the natural ecosystem? Could the DNA we inserted into a specific bacteria be transmitted, with unknown spread of information?
Biological vs. Xenobiological strategies
Biological strategies
Xenobiological strategies
Reference:
- Wright, O., Stan, G.-B., and Ellis, T. (2013). Building-in biosafety for synthetic biology. (Review) Microbiology, 159, 1221-1235. http://www.ncbi.nlm.nih.gov/pubmed/23519158
- Okada, K., Minehira, M., and Zhu, X. (1997). The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli. Journal of Bacteriology, 179, 3058–3060. http://www.ncbi.nlm.nih.gov/pubmed/9139929
- Søballe, B. , Poole, K. R. (1999). Microbial ubiquinones: multiple roles in respiration, gene regulation and oxidative stress management. (Review) Microbiology, 145, 1817-1830. http://www.ncbi.nlm.nih.gov/pubmed/10463148
- Schmidt, M (2010). Xenobiology: A new form of life as the ultimate biosafety tool Bioessays, 32, 322-331. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909387/
- Malyshev, D.A., Dhami, K., Lavergne, T. et al. (2014). A semi-synthetic organism with an expanded genetic alphabet Nature, 509, 385-388. http://www.nature.com/nature/journal/v509/n7500/full/nature13314.html
