Team:Caltech/Safety

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<a id='modeling' href="https://2014.igem.org/Team:Caltech/Modeling"style="color:#000000"> Modeling</a></td>
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<a id='modeling' href="https://2014.igem.org/Team:Caltech/TXTL"style="color:#000000"> TXTL Promoter Characterization</a></td>
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<tr><td > <h3> Welcome! </h3></td>
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<tr> <td bgColor=#FFFFFF colspan = 3 height = 100px> <font size = +5> <center> Safety </center> </font>
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<br><a href="https://igem.org/Safety/Safety_Form?team_id=1369">Link to our team's safety form.</a> </td> </tr>
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<tr> <td bgColor=#000000 colspan = 3> <font color = "white"> <font size = +2> <center> W.M. Keck Engineering Laboratories </center> </font> </td>
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<p> Visit the iGEM's official <a href="https://2014.igem.org/Safety" >Safety Hub</a> to see this year's safety requirements and get more general information about safety requirements for iGEM teams. The Safety Hub is the central page for everything related to safety in iGEM, general biosafety topics, and future implications of iGEM projects.</p>
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<p><marquee><img src="https://static.igem.org/mediawiki/2014/5/5a/20140709_135423.jpg" height=400 width=600><!--<img src="https://static.igem.org/mediawiki/2014/5/53/20140709_135414.jpg" height = 600 width=400>--><img src="https://static.igem.org/mediawiki/2014/c/c6/20140709_135301.jpg" height = 400 width = 600></marquee></p>
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<tr> <td bgColor=#000000 colspan = 3> <font color = "white"> <font size = +2> <center> Our Lab Space </center> </font> </td>
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<p><marquee><img src="https://static.igem.org/mediawiki/2014/0/09/20140709_135202.jpg" height=400 width=600><img src="https://static.igem.org/mediawiki/2014/2/25/20140709_135155.jpg" height = 400 width=600><img src="https://static.igem.org/mediawiki/2014/2/23/20140709_135147.jpg" height = 400 width = 600><img src="https://static.igem.org/mediawiki/2014/e/e5/20140709_135135.jpg" height=400 width=600></marquee></p>
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<center>Our lab is located on the 1st floor of W. M. Keck Engineering Laboratories. We have our own tabletop centrifuge and thermal cycler, as well as a 37&deg;C incubator, a -20&deg;C freezer, and a 4&deg;C freezer. We share the -80&deg;C freezer with the rest of the Richard Murray lab.
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<h3> Edit this page!</h3>
 
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Please use this page to write about anything related to safety in your project. <!--Be sure to talk about both
 
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<li> <a href=" ">Learn about lab Safety for Today</a></li>
 
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<li> <a href="">Learn about Safety for the future of your project.</a></li>
 
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<h3> Your Lab </h3>
 
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<p><marquee><img src="https://static.igem.org/mediawiki/2014/5/5a/20140709_135423.jpg" height=400 width=600><img src="https://static.igem.org/mediawiki/2014/5/53/20140709_135414.jpg" height = 600 width=400><img src="https://static.igem.org/mediawiki/2014/c/c6/20140709_135301.jpg" height = 400 width = 600></marquee></p>
 
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<tr> <td bgColor=#000000 colspan = 3> <font color = "white"> <font size = +2> <center> Safety Regarding Policies and Practices </center> </font> </td>
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<tr> <td> One of the questions are team asked was: if we were to design an inter species drug to treat diabetes, how feasible would it be to test and distribute?After considering this idea, we came across questions regarding the safety of this approach. We contacted the Caltech Safety Office to consider the steps we would have to take to test it. First, we would want to test our drug on animals. To do this, we would have to adhere to the IACUC guidelines for animal testing. <a href="https://iacuc.caltech.edu/submission">This link</a> describes the procedures necessary. Next, we would want to test it on humans. For that, we would need to adhere to <a href="https://irb.caltech.edu/protocols">the IRB guidelines</a>. Not only do we need to follow IRB guidelines, but we also need to follow FDA guidelines. Their regulations can be found at <a href="http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/ucm155713.htm#FDARegulations">the FDA's website</a> for guidelines regarding clinical trials.
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This approach does address our question. However, it makes it seem like a trivial process, when it, in reality, would be very time consuming to perform. Since we were unsuccessful in creating our circuit design in <i>E. coli</i>, this approach did not influence our science project, since it is a distant step in the process. However, an actual research group or biotech company working on a project similar to ours over a much longer time scale (e.g. 8 years) will almost certainly encounter these concerns and have to account for them accordingly. Future iGEM teams can follow these steps if they build off our work and design a successful circuit in <i>E. coli</i> using insulin.
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<p> Use this section to tell us about your laboratory. Where is it located? What sort of equipment do you use every day? Have you decorated it for the summer? How do you look wearing a lab coat? Take pictures! Show off your space! </p>  
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<tr> <td bgColor=#000000 colspan = 3> <font color = "white"> <font size = +2> <center> Procedures </center> </font> </td>
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[Put in an image of "W.M Keck Engineering laboratories" or whatever is on the front of the building]
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<tr><td>Please visit our <a href="https://2014.igem.org/Team:Caltech/Project/Methods_and_Methods">Materials and Methods section</a> to view the standard protocols we followed over the summer.</td></tr>
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<p> Our lab is located on the 1st floor of W. M. Keck Engineering Laboratories. We have our own tabletop centrifuge and thermal cycler, as well as a 37&deg;C incubator, a -20&deg;C freezer, and a 4&deg;C freezer. We share the -80&deg;C freezer with the rest of the Richard Murray lab. Also, there's a giant whiteboard blocking our path in middle of the workspace that hopefully will be tacked up on the wall where it belongs sometime before the end of summer.</p>
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Our lab space looks like an abandoned construction site! [Put in an image of the lab before renovations]<br>
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____ looks like (s)he's having so much fun in the lab! [Put in an image of ____ setting up like 60 TXTL reactions or something]<br>
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Oh no, the boxes!!! [Put in an image of boxes in the dumpster]<br>
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The autoclave likes to hiss and make threatening noises at us as we work [Put in an image of autoclave running]<br>
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Latest revision as of 22:01, 17 October 2014



Home Team Official Team Profile Project Parts TXTL Promoter Characterization Notebook Safety Attributions
Safety

Link to our team's safety form.
W.M. Keck Engineering Laboratories

Our Lab Space

Our lab is located on the 1st floor of W. M. Keck Engineering Laboratories. We have our own tabletop centrifuge and thermal cycler, as well as a 37°C incubator, a -20°C freezer, and a 4°C freezer. We share the -80°C freezer with the rest of the Richard Murray lab.
Safety Regarding Policies and Practices
One of the questions are team asked was: if we were to design an inter species drug to treat diabetes, how feasible would it be to test and distribute?After considering this idea, we came across questions regarding the safety of this approach. We contacted the Caltech Safety Office to consider the steps we would have to take to test it. First, we would want to test our drug on animals. To do this, we would have to adhere to the IACUC guidelines for animal testing. This link describes the procedures necessary. Next, we would want to test it on humans. For that, we would need to adhere to the IRB guidelines. Not only do we need to follow IRB guidelines, but we also need to follow FDA guidelines. Their regulations can be found at the FDA's website for guidelines regarding clinical trials.

This approach does address our question. However, it makes it seem like a trivial process, when it, in reality, would be very time consuming to perform. Since we were unsuccessful in creating our circuit design in E. coli, this approach did not influence our science project, since it is a distant step in the process. However, an actual research group or biotech company working on a project similar to ours over a much longer time scale (e.g. 8 years) will almost certainly encounter these concerns and have to account for them accordingly. Future iGEM teams can follow these steps if they build off our work and design a successful circuit in E. coli using insulin.

Procedures
Please visit our Materials and Methods section to view the standard protocols we followed over the summer.