Team:Aachen/Project/Gal3

From 2014.igem.org

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= Background =
= Background =
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Galectins are proteins of the lectin family, which posess carbonhydrate recognition domains binding specifically to β-galactoside sugar residues. In humans 10 different galectines have been identified, among which is galectin-3.
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Galectin-3 has a size of about 30kDA and is encoded by a single gene, LGALS3. It has many physiological functions, such as cell adhesion, cell growth and differentiation, and contribute to the development of cancer, inflammation, fibrosis and others.
= Idea =
= Idea =
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The specific binding of galectin-3 enables the construction of a detetcion system. Parts of the lipopolysaccharide structure (LPS) of '''Pseudomonas aeruginosa''' can be bound by galectin-3. A fusion protein of galectin-3 and a reporter protein, such as a fluorescent protein, can be built with which '''Pseudomonas aeruginosa''' can be detected.
= Aims =
= Aims =
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The galectin-
= Achievements =
= Achievements =

Revision as of 15:55, 6 October 2014

Background

Galectins are proteins of the lectin family, which posess carbonhydrate recognition domains binding specifically to β-galactoside sugar residues. In humans 10 different galectines have been identified, among which is galectin-3.

Galectin-3 has a size of about 30kDA and is encoded by a single gene, LGALS3. It has many physiological functions, such as cell adhesion, cell growth and differentiation, and contribute to the development of cancer, inflammation, fibrosis and others.

Idea

The specific binding of galectin-3 enables the construction of a detetcion system. Parts of the lipopolysaccharide structure (LPS) of Pseudomonas aeruginosa can be bound by galectin-3. A fusion protein of galectin-3 and a reporter protein, such as a fluorescent protein, can be built with which Pseudomonas aeruginosa can be detected.

Aims

The galectin-

Achievements

References