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| </ul> | | </ul> |
| </nav> | | </nav> |
- | <aside style="height: 260px;"></aside> | + | <aside style="height: 1000px;"></aside> |
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| <section> | | <section> |
| <h2>Abstract</h2> | | <h2>Abstract</h2> |
- | <p> <i><b> Type I diabetes mellitus </b></i> (T1DM) affects more than 17 million people worldwide, and current treatments for T1DM, known as <i><b> insulin therapy </b></i>, require continued insulin injection, diet control, and constant monitoring of blood sugar. <i><b> Gene therapy </b></i> methods that restore insulin production in non-pancreatic cells might provide a <i><b> one-shot cure </b></i> for T1DB. We propose a gene therapy for T1DM using an <i><b> adeno-associated viral </b></i> (AAV) vector that transfects somatic cells with an insulin gene controlled by a glucose-sensitive promoter, thus potentially restoring <i><b> glucose-dependent </b></i> insulin production in diabetic patients. Preliminary tests are conducted on cell lines to assess the efficiency of the therapy.</p> | + | <p> <i><b> Type I diabetes mellitus </b></i> (T1DM) affects more than 17 million people worldwide, and current treatments for T1DM, known as <i><b> insulin therapy </b></i>, require continued insulin injection, diet control, and constant monitoring of blood sugar. <i><b> Gene therapy </b></i> methods that restore insulin production in non-pancreatic cells might provide a <i><b> one-shot cure </b></i> for T1DB. We propose a gene therapy for T1DM using an <i><b> adeno-associated viral </b></i> (AAV) vector that transfects somatic cells with an insulin gene controlled by a glucose-sensitive promoter, thus potentially restoring <i><b> glucose-regulated </b></i> insulin production in diabetic patients. Preliminary tests are conducted on cell lines to assess the efficiency of the therapy.</p> |
| </section> | | </section> |
| <section><p> </p></section> | | <section><p> </p></section> |
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| <section> | | <section> |
| <h2>Background</h2> | | <h2>Background</h2> |
| + | <p>Interested? Click on any of the icons below to get more information on Diabetes and Gene Therapy.</p> |
| <div class="iconContainer_200"> | | <div class="iconContainer_200"> |
| <div class="iconLeft_200" id="intro_diabetes" onclick="location.href='https://2014.igem.org/Team:Tsinghua/Introduction/Diabetes'"></div> | | <div class="iconLeft_200" id="intro_diabetes" onclick="location.href='https://2014.igem.org/Team:Tsinghua/Introduction/Diabetes'"></div> |
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| </div> | | </div> |
| </section> | | </section> |
| + | <section> |
| + | |
| + | <h2>Achievements</h2> |
| + | <h3>Bronze Medal:</h3> |
| + | <ul> |
| + | <li>We have registered our team, have a great summer, and plan to have fun at the Giant Jamboree.</li> |
| + | |
| + | <li>We have successfully completed and submitted the iGEM 2014 Judging form.</li> |
| + | |
| + | <li>We have created and shared a Description of the team's project using the iGEM wiki and the team's parts using the Registry of Standard Biological Parts.</li> |
| + | |
| + | <li>We have already planned to present a Poster and Talk at the iGEM Jamboree.</li> |
| + | |
| + | <li>We have designed and built four standard biobricks in our project, |
| + | <ul> |
| + | <li><a href="http://parts.igem.org/Part:BBa_K1328000">BBa_K1328000</a></li><li><a href="http://parts.igem.org/Part:BBa_K1328002">BBa_K1328002</a></li><li><a href="http://parts.igem.org/Part:BBa_K1328003">BBa_K1328003</a></li><li><a href="http://parts.igem.org/Part:BBa_K1328004">BBa_K1328004</a></li> |
| + | </ul> |
| + | </li> |
| + | </ul> |
| + | |
| + | <h3>Silver Medal:</h3> |
| + | <ul> |
| + | |
| + | <li>Experimentally validate that more than one new BioBrick Part of our own design and construction works as expected.</li> |
| + | |
| + | <li>We have documented the characterization of all the part in the Main Page section of that Part's/Device's Registry entry.</li> |
| + | |
| + | <li>We have submitted our four new parts to the iGEM Parts Registry.</li> |
| + | |
| + | <li>Beyond the bench, we did the team communication, talked to young students, reached out to Fellow Scholars and made a movie explaining the good and bad of the virus.</li> |
| + | </ul> |
| + | <h3>Gold Medal:</h3> |
| + | <ul> |
| + | |
| + | <li>We assisted Tsinghua-A in preparing their parts for submission and helping them with shipping.</li> |
| + | |
| + | <li>We provided consultation to BNU-China when they started their first team. </li> |
| + | |
| + | <li>We sent 8 of our parts from our team DNA repository to NUDT-China team to help them start their experiments. Some of these parts were created by Team Tsinghua for iGEM 2013 and others were from the DNA distribution kit from 2013.</li> |
| + | </ul> |
| + | |
| + | <h3>Policy and Practices</h3> |
| + | <p><a href="https://2014.igem.org/Team:Tsinghua/Human_practice">Click here</a> for a link to our Policy Practices page (Human Practices)</p> |
| + | <ul> |
| + | <li><a href="https://2014.igem.org/Team:Tsinghua/Human_practice/Gallery">The Future of Synthetic Biology</a></li> |
| + | <li><a href="https://2014.igem.org/Team:Tsinghua/Human_practice/Outreach">Reaching out to Fellow Scholars</a></li> |
| + | <li><a href="https://2014.igem.org/Team:Tsinghua/Human_practice/Video">"Virus" - the Short Movie</a></li> |
| + | </ul> |
| + | |
| + | </section> |
| <!-- end .content --></article> | | <!-- end .content --></article> |
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