Team:Paris Bettencourt

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<p class=definition><b>It has always been the objective of iGEM Paris Bettencourt to conduct novel projects.  
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<p class=definition><b>Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few. </b></p>
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This year, our team has decided to explore a topic that has rarely been approached by
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<p class=definition>The <b>iGEM Paris Bettencourt 2014 </b>project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.</p>
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synthetic biologists in this competition: odor.</b></p>
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<p class=definition> Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell <i>just like themselves</i>.</p>
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<p class=definition>Human olfaction relies on a tremendous number of cellular receptors that can detect
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specific molecules in the air. Upon the detection of combination of these compounds, a
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        <div id=results><a href="https://2014.igem.org/Team:Paris_Bettencourt/Results"><img src="https://static.igem.org/mediawiki/2014/8/85/Gotoresultspb.png"></br><p>Jump To Results</p></a></div>
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message is sent to the brain, which leads to the perception of one unique odor. There is
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                        </div>
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considerable work left to do in order to understand the sense of smell, especially in
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determining how olfactory receptors operate. Few synthetic biologists have tried to
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engineer bacteria to produce smell or to treat bad smell since the production of odor by
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microorganisms is not studied often. One reason for the lack of study in this area is that
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it is hard to quantify and characterize an odor. We will overcome this by using odor pro-
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fessionals and commonly used scientific tools. We want to do this in order to investigate
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the links between our skin microbiota and body odor, as well as the perception of one's
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body odor by others.</p>
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</div>
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<div id=smell><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Odor_Library"><p class=descript2>Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.</p><img src="https://static.igem.org/mediawiki/2014/b/b1/Smelltheroses.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/c/ca/Smelltherosesrose.png" class=nameimgr></a></div>
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                <div class=separation></div>
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<div id=fish><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/TMAU"><p class=descript2>Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor to appear in the sweat. Here we engineer skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme TMM (trimethylamine monooxygenase).</p><img src="https://static.igem.org/mediawiki/2014/b/b9/Somethingfishy.png" id=fishy class=nameimg><img src="https://static.igem.org/mediawiki/2014/f/fd/Somethingfishyrosepb.png" id=fishy class=nameimgr></a></div>
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                <div class=separation></div>
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<div id=shoes><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Foot_Odor"><p class=descript2>Isovaleric acid, the cheesy component of foot odor, is produced by <i>B. subtilis</i> through the leucine degradation pathway. We characterize <i>B. subtilis</i> mutants in this pathway, in vitro and in situ (on socks).</p><img src="https://static.igem.org/mediawiki/2014/3/3a/Goodytwoshoes.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/d/dd/Goodytwoshoesrosepb.png" class=nameimgr></a></div>
 +
                <div class=separation></div>
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<div id=sweat><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Eliminate_Smell"><p class=descript2>Armpit odor comes mainly from aminoacylase enzymes expressed in the genus <i>Corynebacteria</i>. This project is developing CRISPR technology to isolate natural bacterial mutants that lack these enzymes.</p><img src="https://static.igem.org/mediawiki/2014/e/e1/Dontsweatit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/a/ac/Dontsweatitrosepb.png" class=nameimgr></a></div>
 +
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<div id=teen><a class=layout href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Old_People_Smell"><p class=descript2>2-nonenal is "old people smell," a component of sweat that increases with age. Here we isolate and characterize bacterial species that metabolize 2-nonenal and attenuate its characteristic odor.</p><img src="https://static.igem.org/mediawiki/2014/6/6f/Teenspirit.png" class=nameimg><img src="https://static.igem.org/mediawiki/2014/5/57/Teenspiritrosepb.png" class=nameimgr></a></div>
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 +
<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/The_Smell_Game"><img src="https://static.igem.org/mediawiki/2014/e/e7/PBiconesmellgame.png"></a></td><td></td>
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                                <td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Project/Art"><img src="https://static.igem.org/mediawiki/2014/3/39/PBiconedesign.png"></a></td>
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<td><a href="https://2014.igem.org/Team:Paris_Bettencourt/Newsletter"><img src="https://static.igem.org/mediawiki/2014/7/75/PBiconnews.png"></a></td><td></td>
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 +
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 +
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{{:Team:Paris_Bettencourt/Footer}}

Latest revision as of 18:43, 5 December 2014


Body odor is caused by the metabolic action of bacteria on human sweat. Existing deodorants are antibiotic - they kill all skin bacteria including neutral and beneficial species. Where body odor carries a social stigma, alternatives to deodorant are few.

The iGEM Paris Bettencourt 2014 project explores new ways to control body odors through precise modifications of the living microbiome. We target common odors of the armpit and foot, as well as odors specific to old age or genetic disease. We present a BioBrick smell library for mixing genetic perfumes and a CRISPR-mediated technology for isolating naturally odorless bacterial strains.

Our work represents a probiotic and body-positive approach to body odor that will someday help people to smell just like themselves.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
Copyright (c) 2014 igem.org. All rights reserved.

Retrieved from "http://2014.igem.org/Team:Paris_Bettencourt"