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<p>
<p>
<b>SilverSURF</b>
<b>SilverSURF</b>
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<span>Environmental pollution with harmful quantities of heavy metal ions has become an urgent problem in these times.  
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<span>Environmental pollution with harmful quantities of heavy metal ions has become an urgent problem.<br />SilverSURF makes use of the flagellar filament that represents one of the largest scaffolds in nature, and combines it with the unique potential of high-affinity metal-ion-binding domains.
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SilverSURF makes use of the flagellar filament that represents one of the largest scaffolds in nature.</span>
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</span>
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</p>
</a>
</a>
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<p>
<b>CancerSURF</b>
<b>CancerSURF</b>
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<span>Lung cancer is one of the most malignant cancers with poor prognosis. Next to the common therapies like surgery,
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<span>Lung cancer is one of the most malignant cancers with poor prognosis.<br />CancerSURF combines the scaffold of a tetrameric Streptavidin to increase the specificity of a DARPin to detect a prominent tumor marker. This system can find several applications in medical treatment or as a diagnostic tool.
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radiation therapy and chemotherapy, antibody therapy is more specific.  
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</span>
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</div> <!-- end wrap -->
</div> <!-- end wrap -->
<div class="wrap">
<div class="wrap">
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<a href="https://2014.igem.org/Team:Marburg:Project:Tumor" aria-haspopup="true">
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<a href="https://2014.igem.org/Team:Marburg:Project:NRPS" aria-haspopup="true">
<img src="https://static.igem.org/mediawiki/2014/8/86/MR_start_riboSURF.png" alt="RiboSURF">
<img src="https://static.igem.org/mediawiki/2014/8/86/MR_start_riboSURF.png" alt="RiboSURF">
<i>&nbsp;</i>
<i>&nbsp;</i>
<p>
<p>
<b>RiboSURF</b>
<b>RiboSURF</b>
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<span>Ribosomes synthesize proteins from amino acids using mRNA as blueprint and tRNAs delivering amino acids. However,
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<span>Ribosomes are limited to 20 L-amino acids while non-ribosomal peptide synthetases (NRPSs) can use a large number of natural and non-proteinogenic amino acids. RiboSURF aims at combining the huge repertoire of NRPSs with ribosomal protein synthesis to extend the synthetic scope of the ribosome.
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the natural ability of ribosomes is limited to 20 L-amino acids. Non-ribosomal peptide synthetases (NRPSs) synthesize
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only small peptides, however, from a large number of natural and non-proteinogenic amino acids.
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with non-proteinogenic amino acids.  
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<p>
<p>
<b>SURFkiller</b>
<b>SURFkiller</b>
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<span>The work with genetically modified organisms (GMOs) harbours the risk of their release to the nature. After release,  
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<span>The work with genetically modified organisms (GMOs) harbours the risk of their release into nature. Therefore, it is necessary to make their survival in nature impossible.<br />We developed a security system for <em>Bacillus subtilis</em> based on one of the cells essential compartment the ribosome.  
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serious consequences such as gene exchange with unmodified organism or ecosystem imbalance cannot be excluded.
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</span>
</span>
</p>
</p>

Latest revision as of 12:19, 23 November 2014

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