Team:ULB-Brussels

From 2014.igem.org

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<tr style="background-color:rgb(245,245,245); box-shadow: 1px 1px 12px #555;"><td colspan="2"><p class="title"> Welcome to our website</p></td></tr>
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<section style="text-align: justify; margin: 25px"><p>This year, the <i>Université Libre de Bruxelles</i> competes again in the International Genetically Engineered Machines contest, </l>a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.</p>
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<p>Our team will present a new system aiming to fight against the emergence of unproductive cell sub-populations in bioreactors by coupling recombinant protein production with a essential protein, thus addicting cells to production. We hope this system will significantly increase production in fermenters and bioreactors. For more information, please see the page dedicated to the project.</p>
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<section style="text-align: justify; margin: 25px"><p>$\Tgo\hspace{-0.145cm}$his year, the Université Libre de Bruxelles competes again in the International Genetically Engineered Machines contest, a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.<br><br>
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<p>On this website, you can also find all the details about our sponsors and the evolution of the project. Feel free to browse. -Website optimized on Mozilla Firefox-</p></section>
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Our aim is to enhance recombinant protein production in bioreactors by addicting microorganisms to the production of a protein of interest (PI).  
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We built $\MyColi$, a recombinant <i>Escherichia Coli</i> expressing a toxin and the PI. This protein will be on the same open reading frame as an antoxin, a protein able to neutralize the effects of the toxin. Stressed subpopulations might not express the PI (and thus the antitoxin) to a sufficient level, allowing the toxin to kill unproductive cells. Our work will consist on building and modelling this system throughout the summer.  </p></section>
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Latest revision as of 18:11, 17 October 2014

$~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\MyColi}{{\small Mighty\hspace{0.12cm}Coli}} \newcommand{\Stabi}{\small Stabi}$ $\newcommand{\EColi}{\small E.coli} \newcommand{\SCere}{\small S.cerevisae}\\[0cm] ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ \newcommand{\PI}{\small PI}$ $\newcommand{\Igo}{\Large\mathcal{I}} \newcommand{\Tgo}{\Large\mathcal{T}} \newcommand{\Ogo}{\Large\mathcal{O}} ~$ Example of a hierarchical menu in CSS

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- Université Libre de Bruxelles -


$Welcome$ 'to our Website'


$\Tgo\hspace{-0.145cm}$his year, the Université Libre de Bruxelles competes again in the International Genetically Engineered Machines contest, a competition of synthetic biology organized by the Massachussetts Institute of Technology. Year 2014 will mark the 10th anniversary of the IGEM and will feature a "Giant Jamboree", where all teams will be invited in Boston without regional pre-selection.

Our aim is to enhance recombinant protein production in bioreactors by addicting microorganisms to the production of a protein of interest (PI). We built $\MyColi$, a recombinant Escherichia Coli expressing a toxin and the PI. This protein will be on the same open reading frame as an antoxin, a protein able to neutralize the effects of the toxin. Stressed subpopulations might not express the PI (and thus the antitoxin) to a sufficient level, allowing the toxin to kill unproductive cells. Our work will consist on building and modelling this system throughout the summer.



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