Team:Tsinghua

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<title>Tsinghua iGEM</title>
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<h1 class="customtext">Hi! We are <font color="990099">Team Tsinghua</font>. We present to you a <font color="990099">gene therapy</font> for Type 1 Diabetes Mellitus (T1DM).</h1>  
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<h1 class="customtext"><font color="990099">T1DM</font> results from autoimmune destruction of pancreatic beta cells. Our approach converts somatic cells into regulated insulin-producing cells, thus eliminating the need for continuous insulin therapy.</h1>
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<h1 class="customtext">We use <font color="990099">Adeno-associated virus (AAV)</font> as a transfection vector to introduce genes, which has proven to be safe… Well, that’s a whole other story, want to know more? </h1>
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<a href="https://2014.igem.org/Team:Tsinghua/Main_page">Get Started!</a>
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      <li><a href="#">MAIN PAGE</a></li>
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      <li><a href="#">INTRODUCTION</a></li>
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      <li><a href="#">PROJECT</a>
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          <li><a href="#">Tet-Insulin</a></li>
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      <li><a href="#">RESULTS</a>
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    <h1>Introduction</h1>
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    <h2>TYPE I DIABETES MELLITUS</h2>
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      <p>Diabetes mellitus is a chronic disease involving excessively high levels of blood glucose, either due to absence of insulin production (Type I), or decreased insulin production or insulin receptor dysfunction (Type II). Diabetes can be fatal if left untreated. A study estimates 366 million people are affected by diabetes worldwide, and predicts the number to rise to 552 million by the end of 2030<sup>[1]</sup>.</p>
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  <p>Type I diabetes mellitus (T1DM) account for 5 % – 10 %<sup> [3, 4]</sup> of diabetes cases. Nonetheless, a cure or prevention for T1DM does not yet exist. Type I diabetes can occur anytime in life, and is most prevalent in children and teenagers aged 8 – 16. The causes for type I diabetes remains unclear, it is, however, most commonly attributed to autoimmune destruction of insulin-producing pancreatic beta cells.</p>
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  <p><a href="https://static.igem.org/mediawiki/2014/1/19/Tsinghua_intro_fig_1.jpg"><img src="https://static.igem.org/mediawiki/2014/1/19/Tsinghua_intro_fig_1.jpg" alt="" width=480 height=249></a></p>
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  <p>Figure 1. An estimation of type I diabetes global incidence by region. Data shown are cases per 100,000 people. (Adapted from [2])</p>
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  <p>Currently, the primary treatment for T1DM is insulin therapy, which involves daily injections of insulin and constant monitoring of blood glucose levels as well as food intake. Insulin pumps and continuous blood glucose monitors are increasingly utilized to ameliorate the need for constant care. However, insulin therapy requires regular, if not constant, maintenance, and is by no means considered a cure.</p>
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  <p>There are attempts at developing a cure for T1DM, either through islet transplantation or stem cell regeneration, which would restore insulin production in T1DM patients. A more novel approach involves gene therapy, aimed at granting somatic cells other than beta cells the ability to produce insulin via artificial gene transfer.</p>
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  <p>[1] Whiting, David R., et al.  &quot;IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011  and 2030.&quot;&nbsp;<em>Diabetes  research and clinical practice</em>&nbsp;94.3  (2011): 311-321.<br>
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    [2] Mark A Atkinson, George S  Eisenbarth, Aaron W Michels, Type 1 diabetes, The Lancet, Volume 383, Issue  9911, 4–10 January 2014, Pages 69-82, ISSN 0140-6736, http://dx.doi.org/10.1016/S0140-6736(13)60591-7.<br>
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    [3]  Type 1 diabetes, American Diabetes Association. <a href="http://www.diabetes.org/diabetes-basics/type-1/">http://www.diabetes.org/diabetes-basics/type-1/</a> <br>
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      [4]  Type 1 diabetes, NHS. <a href="http://www.nhs.uk/conditions/Diabetes-type1/Pages/Introduction.aspx">http://www.nhs.uk/conditions/Diabetes-type1/Pages/Introduction.aspx</a></p>
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      <p>Because all the columns are floated, this layout uses a clear:both declaration in the footer rule.  This clearing technique forces the .container to understand where the columns end in order to show any borders or background colors you place on the .container. If your design requires you to remove the footer from the .container, you'll need to use a different clearing method. The most reliable will be to add a &lt;br class=&quot;clearfloat&quot; /&gt; or &lt;div  class=&quot;clearfloat&quot;&gt;&lt;/div&gt; after your final floated column (but before the .container closes). This will have the same clearing effect. </p>
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      <p> Be aware that if you use the Property inspector to navigate to your logo image using the SRC field (instead of removing and replacing the placeholder), you should remove the inline background and display properties. These inline styles are only used to make the logo placeholder show up in browsers for demonstration purposes. </p>
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      <p>To remove the inline styles, make sure your CSS Styles panel is set to Current. Select the image, and in the Properties pane of the CSS Styles panel, right click and delete the display and background properties. (Of course, you can always go directly into the code and delete the inline styles from the image or placeholder there.)</p>
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Latest revision as of 18:20, 15 October 2014

Hi! We are Team Tsinghua. We present to you a gene therapy for Type 1 Diabetes Mellitus (T1DM).

Scroll down

T1DM results from autoimmune destruction of pancreatic beta cells. Our approach converts somatic cells into regulated insulin-producing cells, thus eliminating the need for continuous insulin therapy.

Scroll down

We use Adeno-associated virus (AAV) as a transfection vector to introduce genes, which has proven to be safe… Well, that’s a whole other story, want to know more?

Scroll down

Retrieved from "http://2014.igem.org/Team:Tsinghua"