Team:Paris Bettencourt/Project/Old People Smell

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<h6>Introduction</h6><br>
<h6>Introduction</h6><br>
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<p>Body odor is a unique characteristic of each individual. Our body aroma could change with shifts in diet, physical activity, and age. Previous research has demonstrated that people are able to correctly identify the age of an unknown person based exclusively on their body odor [1]. This research confirmed that 'aging odor' or 'old person smell' does really exist. Moreover, Japanese researchers identified the volatile molecule that is positively correlated with age and significantly detectable for the people over 40 year old. [2]</p>
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Body odor is a unique characteristic of each individual. Our body aroma could change with shifts in diet, physical activity, and age. Previous research has demonstrated that people are able to correctly identify the age of an unknown person based exclusively on their body odor [1]. This research confirmed that 'aging odor' or 'old person smell' does really exist. Moreover, Japanese researchers identified the volatile molecule that is positively correlated with age and significantly detectable for the people over 40 year old. [2]</p>
<p>This molecule is an unsaturated aldehyde 2-nonenal with a characteristic scent described in the literature as a combination of orris, cucumber, and fat.[3] According to Haze et al. [2] the 2-nonenal is formed by oxidative degradation of skin surface lipids, accelerated by lipid peroxides. However, it is not clear if these fatty acids on the skin are initially degraded by skin microbiome or other agents [2].
<p>This molecule is an unsaturated aldehyde 2-nonenal with a characteristic scent described in the literature as a combination of orris, cucumber, and fat.[3] According to Haze et al. [2] the 2-nonenal is formed by oxidative degradation of skin surface lipids, accelerated by lipid peroxides. However, it is not clear if these fatty acids on the skin are initially degraded by skin microbiome or other agents [2].
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Revision as of 14:44, 9 October 2014

BACKGROUND

  • 2-nonenal is a volatile compound associated with the ageing process.
  • 2-nonenal’s odor is described as a combination of cucumber, orris, and fat.
  • The overabundance of 2-nonenal on the skin of 40+ year-old people comes from the breakdown of omega-7 fatty acids.

AIMS

  • Model the 2-nonenal diffusion from the skin to the air
  • Recreate the conditions of old person skin, which contains 2-nonenal
  • Discover or evolve bacteria to enable the breakdown of 2-nonenal

RESULTS

  • Modelled the diffusion of a 2-nonenal from the skin through the air.
  • Discovered bacterial species capable of growing in nutrient poor media with 2-nonenal as the primary carbon source
  • Measured toxicity threshold of 2-nonenal
  • Determined the smell detection limit of 2-nonenal

Introduction Motivation Aims Results

Introduction

Body odor is a unique characteristic of each individual. Our body aroma could change with shifts in diet, physical activity, and age. Previous research has demonstrated that people are able to correctly identify the age of an unknown person based exclusively on their body odor [1]. This research confirmed that 'aging odor' or 'old person smell' does really exist. Moreover, Japanese researchers identified the volatile molecule that is positively correlated with age and significantly detectable for the people over 40 year old. [2]

This molecule is an unsaturated aldehyde 2-nonenal with a characteristic scent described in the literature as a combination of orris, cucumber, and fat.[3] According to Haze et al. [2] the 2-nonenal is formed by oxidative degradation of skin surface lipids, accelerated by lipid peroxides. However, it is not clear if these fatty acids on the skin are initially degraded by skin microbiome or other agents [2].

Motivation

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Aims

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Results

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Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
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