Team:Paris Bettencourt/Project

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SMELL THE ROSES

Here we present a genetic odor palette. It is built of BioBricks to express enzymes to produce volatile compounds with characteristic smells. We included smells with different tonalities to allow exploration of the "odor space" resulting from combinations of smelly units.

SOMETHING FISHY

Trimethylaminuria (TMAU) is a rare genetic disease causing a strong fish odor. Our project aims at engineering skin bacteria to degrade trimethylamine, the odor causing molecule, with the enzyme trimethylamine monooxygenase (TMM).

GOODY TWO SHOES

Isovaleric acid is a compound produced by B. subtilis through leucine degradation pathway, which is hypothesized to be responsible for the foot odor (cheese smell.) Our project aims at validating this hypothesis with the aid of both invitro and insitu experimentation's.

DON'T SWEAT IT

Bacteria processing sweat is the major responsible of body odor. Our project aims to study the bacteria involved in the creation of malodorous compounds and try to find natural variant that are odorless. The final goal is to create a probiotic cosmetic.

TEEN SPIRIT

2-nonenal is a compound with very specific strong odor perceived as iris, fat, and cucumber, which rate increases with age. Our goal is to study relationship between human skin bacteria and 2-nonenal.

ART

2-nonenal is a compound, with very specific strong odor perceived as iris, fat, and cucumber, which rate increases with age. Our goal is to study relationship between human skin bacteria and 2-nonenal.

BIOINFORMATICS

Bioinformatics tools are used to analyze genes related to body odor in order to better understand gene abundance at various body sites, function and phylogeny.

All humans have a body odor, but sometimes it is unwanted. Our core projects modify the natural human skin flora to change body odors associated with the armpit, foot, fish odor syndrome, or old age.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
paris-bettencourt-igem@googlegroups.com
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