Team:ETH Zurich/modeling/qs

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(Range of validity of the assumptions)
(Model)
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As diffusion through the membrane is very fast<sup>[[Team:ETH_Zurich/project/references|[27]]]</sup>, according to Fick's law of diffusion, internal and external concentration of AHL can always be considered as equal. When an initial external AHL concentration is given, AHL diffuses in the cells very quickly (less than 20 seconds)<sup>[[Team:ETH_Zurich/project/references|[27]]]</sup> until internal AHL concentration equals external concentration. Then as soon as some internal AHL is consumed in the cell, it is taken up again without affecting external concentration, because external volume is very high compared to internal volume. Therefore we can consider in this module that external AHL (which is equal to internal AHL) only degrades, with the rate of extracellular decay.
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As diffusion through the membrane is very fast<sup>[[Team:ETH_Zurich/project/references|[27]]]</sup>, according to Fick's law of diffusion, internal and external concentration of AHL can always be considered as equal. This can also be observed in the [2014.igem.org/Team:ETH_Zurich/modeling/diffmodel#Results diffusion model results]. When an initial external AHL concentration is given, AHL diffuses in the cells very quickly (less than 20 seconds)<sup>[[Team:ETH_Zurich/project/references|[27]]]</sup> until internal AHL concentration equals external concentration. Then as soon as some internal AHL is consumed in the cell, it is taken up again without affecting external concentration, because external volume is very high compared to internal volume. Therefore we can consider in this module that external AHL (which is equal to internal AHL) only degrades, with the rate of extracellular decay.
   
   
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Revision as of 03:46, 17 October 2014

iGEM ETH Zurich 2014