Team:Carnegie Mellon/Project Description

From 2014.igem.org

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    /* CUSTOMIZE THE CAROUSEL
 
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    -------------------------------------------------- */
 
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    /* Carousel base class */
 
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    .carousel {
 
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      margin-bottom: 60px;
 
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    .carousel .container {
 
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      text-shadow: 0 1px 1px rgba(0,0,0,.4);
 
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    .carousel .item {
 
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      height: 500px;
 
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    .carousel img {
 
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      position: absolute;
 
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    .carousel-caption {
 
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    .carousel-caption h1,
 
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    .carousel-caption .lead {
 
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    <!-- Carousel
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    ================================================== -->
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    <div id="myCarousel" class="carousel slide">
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      <div class="carousel-inner">
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        <div class="item active">
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          <img src="https://encrypted-tbn3.gstatic.com/images?q=tbn:ANd9GcTOnyR8iWr-1Ge9YcJHLVPfRX8YYJbeipjsJcPMYcPXgSae5FAlBQ" alt="">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Project Title.</h1>
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              <p class="lead">Our project description...</p>
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            </div>
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          </div>
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        </div>
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        <div class="item">
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          <img src="http://iloveubuntu.net/pictures_me/saucy%20salamander%20gtk_3%203.8.jpg" alt="">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Another example headline.</h1>
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              <p class="lead">Our project description...</p>
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              <a class="btn btn-large btn-primary" href="#">Learn more</a>
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            </div>
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          </div>
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        </div>
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        <div class="item">
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          <img src="http://www.clker.com/cliparts/a/a/5/6/11954240121535699699fzap_salamander.svg.hi.png" alt="">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>One more for good measure.</h1>
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              <p class="lead">Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
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              <a class="btn btn-large btn-primary" href="#">Browse gallery</a>
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            </div>
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          </div>
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        </div>
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      </div>
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      <a class="left carousel-control" href="#myCarousel" data-slide="prev">&lsaquo;</a>
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      <a class="right carousel-control" href="#myCarousel" data-slide="next">&rsaquo;</a>
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    </div><!-- /.carousel -->
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Revision as of 02:53, 12 September 2014

Carousel Template · Bootstrap

S.T.R.E.A.M.

Sensor That Reports Endocrine Activating Molecules

Hormones are molecules that allow cells to communicate with each other and are used by organisms to alter growth and metabolism. The steroid hormones such as estrogen can diffuse across the plasma membrane, bind their receptor in the cytoplasm, migrate to the nucleus and act as transcription factors to alter cell’s physiology and behavior. Naturally occurring steroid hormones include estrogen, progesterone, testosterone and cortisol. 

Detection of hormones in the environment has raised concerns in recent years because of their potential to affect both humans and wildlife. Estrogens from natural, synthetic, plant, and fungal sources can manifest endocrine disrupting properties and even at low concentrations can have harmful effects due to receptor activation. Estrogenic activity can occur in water sources including waste, drinking and freshwater. In freshwater, estrogens are harmful to the ecosystems, feminizing fish and disrupting the overall populations of organisms in the ecosystem. Estrogenic substances can also be present in what we drink, however since the presence of hormones in water is a relatively new area of study, there have been no previous restrictions or regulations regarding filtration of estrogenic compounds. 

Due to concern with the compounds in water, we are developing a sensor to detect the molecules in water that will bind to the estrogen receptor. We anticipate that our STREAM, Sensor That Reports Endocrine Activating Molecules, will be sensitive and informative of water quality. A BioNetGen model of the sensor and NetLogo model of fish populations were constructed to improve our understanding of these systems.

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