http://2014.igem.org/wiki/index.php?title=Team:Calgary&feed=atom&action=historyTeam:Calgary - Revision history2024-03-28T19:40:44ZRevision history for this page on the wikiMediaWiki 1.16.5http://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=401196&oldid=prevAnna.fei at 03:55, 18 October 20142014-10-18T03:55:28Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2">Global Impact</h2></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2">Global Impact</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><del class="diffchange diffchange-inline">The tragedy lies in the fact that patients </del>who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs <del class="diffchange diffchange-inline">and considered to have malaria </del>despite their diagnosis. The over-prescription of antimalarials fosters an environment for the <del class="diffchange diffchange-inline">continued </del>emergence of drug resistance<del class="diffchange diffchange-inline">, unnecessarily taxes healthcare systems, </del>and <del class="diffchange diffchange-inline">most importantly, </del>worsens the patient's condition.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><ins class="diffchange diffchange-inline">Patients </ins>who test negative for malaria but show its clinical signs and symptoms are often given antimalarial drugs despite their diagnosis. The over-prescription of antimalarials fosters an environment for the emergence of <ins class="diffchange diffchange-inline"><b></ins>drug resistance<ins class="diffchange diffchange-inline"></b> </ins>and worsens the patient's condition.</p></div></td></tr>
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</table>Anna.feihttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=400874&oldid=prevDCurran at 03:53, 18 October 20142014-10-18T03:53:11Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2">Global Impact</h2></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2">Global Impact</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><del class="diffchange diffchange-inline">Misdiagnosis prevents the appropriate treatments from being administered </del>in <del class="diffchange diffchange-inline">a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> </del>and <del class="diffchange diffchange-inline">a significant financial burden on </del>the healthcare <del class="diffchange diffchange-inline">system</del>.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><ins class="diffchange diffchange-inline">The tragedy lies </ins>in <ins class="diffchange diffchange-inline">the fact that patients who test negative for malaria but show its clinical signs </ins>and <ins class="diffchange diffchange-inline">symptoms are often given antimalarial drugs and considered to have malaria despite their diagnosis. The over-prescription of antimalarials fosters an environment for </ins>the <ins class="diffchange diffchange-inline">continued emergence of drug resistance, unnecessarily taxes </ins>healthcare <ins class="diffchange diffchange-inline">systems, and most importantly, worsens the patient's condition</ins>.</p></div></td></tr>
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</table>DCurranhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=400245&oldid=prevAnna.fei at 03:48, 18 October 20142014-10-18T03:48:35Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><del class="diffchange diffchange-inline">The Problem</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><ins class="diffchange diffchange-inline">Global Impact</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries, it is predicted that malaria cases <b>will double over the next 20 years</b>. From the public-health perspective, misdiagnosis of malaria results in <b>excessive reporting of malaria cases</b>, while those that mimic malaria are under-reported.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td></tr>
</table>Anna.feihttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=399934&oldid=prevWkeithvan at 03:46, 18 October 20142014-10-18T03:46:27Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><del class="diffchange diffchange-inline">Case Study</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><ins class="diffchange diffchange-inline">The Problem</ins></h2></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><del class="diffchange diffchange-inline">Prevalent infectious diseases such as meningitis</del>, <del class="diffchange diffchange-inline">dengue and typhoid fever are symptomatically similar to </del>malaria, <del class="diffchange diffchange-inline">and are thus often misdiagnosed </del>in <del class="diffchange diffchange-inline">developing countries which </del><<del class="diffchange diffchange-inline">span class="HomeBigText"</del>><del class="diffchange diffchange-inline">LACK THE RESOURCES</del></<del class="diffchange diffchange-inline">span</del>> <del class="diffchange diffchange-inline">to maintain suitable healthcare infrastructures</del>.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP"><ins class="diffchange diffchange-inline">Recent studies show that malaria-endemic countries have a 1-3% decreased economic growth rate than countries without malaria. With a widening gap of prosperity between these group of countries</ins>, <ins class="diffchange diffchange-inline">it is predicted that </ins>malaria <ins class="diffchange diffchange-inline">cases <b>will double over the next 20 years</b>. From the public-health perspective</ins>, <ins class="diffchange diffchange-inline">misdiagnosis of malaria results </ins>in <<ins class="diffchange diffchange-inline">b</ins>><ins class="diffchange diffchange-inline">excessive reporting of malaria cases</ins></<ins class="diffchange diffchange-inline">b</ins>><ins class="diffchange diffchange-inline">, while those that mimic malaria are under-reported</ins>.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td></tr>
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</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=398924&oldid=prevWkeithvan at 03:39, 18 October 20142014-10-18T03:39:27Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2<del class="diffchange diffchange-inline">" style="font-size: 60px;</del>"><i <del class="diffchange diffchange-inline">style="font-size: 60px;"</del>>B.s.</i> Detector</h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2"><i>B.s.</i> Detector</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <img src="https://static.igem.org/mediawiki/2014/8/85/Radialdevice.png" id="HomeDevice"></ins></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <p class="HomeOurDeviceP"><del class="diffchange diffchange-inline">iGEM Calgary 2014 team is using synthetic biology to develop a </del><<del class="diffchange diffchange-inline">span class="HomeBigText"</del>><del class="diffchange diffchange-inline">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</del></<del class="diffchange diffchange-inline">span</del>> <del class="diffchange diffchange-inline">device </del>to <del class="diffchange diffchange-inline">simultaneously diagnose multiple infectious diseases</del>.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <p class="HomeOurDeviceP"><ins class="diffchange diffchange-inline">We are engineering </ins><<ins class="diffchange diffchange-inline">b</ins>><ins class="diffchange diffchange-inline"><i>Bacillus subtilis</ins></<ins class="diffchange diffchange-inline">i</ins>><ins class="diffchange diffchange-inline"></b> to generate chromophoric reporter proteins in response </ins>to <ins class="diffchange diffchange-inline">pathogenic genetic markers</ins>.</p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeComponentsH2">Components of Our System</h2></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeComponentsH2">Components of Our System</h2></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <<del class="diffchange diffchange-inline">p </del>class="<del class="diffchange diffchange-inline">HomeComponentsP</del>"><del class="diffchange diffchange-inline">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013)</del>. <del class="diffchange diffchange-inline">Failure to accurately diagnose such diseases is of particular concern</del>.</<del class="diffchange diffchange-inline">p</del>></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <<ins class="diffchange diffchange-inline">div </ins>class="<ins class="diffchange diffchange-inline">buttoncontainer</ins>"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <div class="button"><a href="https://2014</ins>.<ins class="diffchange diffchange-inline">igem</ins>.<ins class="diffchange diffchange-inline">org/Team:Calgary/Project/BsDetector"><img src="https://static.igem.org/mediawiki/2014/0/00/2014UCalgaryButtonDetector.png"/></a></div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/BsDetector/GeneticCircuit"><img src="https://static.igem.org/mediawiki/2014/c/c5/2014UCalgaryButtonGeneticCircuit.png"/></a></div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <div class="button"><a href="https://2014.igem.org/Team:Calgary/Project/Collaboration"><img src="https://static.igem.org/mediawiki/2014/7/7e/2014UCalgaryButtonCollaboration.png"/></a></div></ins></div></td></tr>
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</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=394118&oldid=prevWkeithvan at 03:07, 18 October 20142014-10-18T03:07:28Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> <del class="diffchange diffchange-inline">DETECTOR</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> <ins class="diffchange diffchange-inline">Detector</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeMisdiagnosisH2"><del class="diffchange diffchange-inline">MISDIAGNOSIS OF INFECTIOUS DESEASES</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeMisdiagnosisH2"><ins class="diffchange diffchange-inline">Misdiagnosis of Infectious Diseases</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeMisdiagnosisP">Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are <b>often misdiagnosed</b> in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a <b>novel, genome-based, rapid point-of-care synthetic biological device</b> to simultaneously diagnose multiple infectious diseases.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeMisdiagnosisP">Infectious diseases such as typhoid fever, meningitis, pneumonia and visceral leishmaniasis have similar clinical manifestations as malaria, thus are <b>often misdiagnosed</b> in resource-poor developing countries lacking suitable medical diagnostic facilities. Failure to properly identify such diseases prevents medical professionals from administering appropriate treatments in a timely manner, which results in economic costs and human suffering. In order to address this issue, the iGEM 2014 team is developing a <b>novel, genome-based, rapid point-of-care synthetic biological device</b> to simultaneously diagnose multiple infectious diseases.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><del class="diffchange diffchange-inline">CASE STUDY</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeCaseStudyH2"><ins class="diffchange diffchange-inline">Case Study</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeOurDevice"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeOurDevice"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeOurDeviceH2"><del class="diffchange diffchange-inline">OUR DEVICE</del>, <del class="diffchange diffchange-inline">OUR IDEA</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeOurDeviceH2"><ins class="diffchange diffchange-inline">Our Device</ins>, <ins class="diffchange diffchange-inline">Our Idea</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeOurDeviceP">iGEM Calgary 2014 team is using synthetic biology to develop a <span class="HomeBigText">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</span> device to simultaneously diagnose multiple infectious diseases.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeOurDeviceP">iGEM Calgary 2014 team is using synthetic biology to develop a <span class="HomeBigText">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</span> device to simultaneously diagnose multiple infectious diseases.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Blue" id="HomeComponents"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Blue" id="HomeComponents"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeComponentsH2"><del class="diffchange diffchange-inline">COMPONENTS OF OUR SYSTEM</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeComponentsH2"><ins class="diffchange diffchange-inline">Components of Our System</ins></h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeComponentsP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases is of particular concern.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeComponentsP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases is of particular concern.</p></div></td></tr>
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</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=393602&oldid=prevWkeithvan at 03:03, 18 October 20142014-10-18T03:03:33Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <img src="https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot.png" id="HomeRobot"></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <h2 class="HomeMisdiagnosisH2"><del class="diffchange diffchange-inline">MALARIA </del>MISDIAGNOSIS</h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <h2 class="HomeMisdiagnosisH2">MISDIAGNOSIS <ins class="diffchange diffchange-inline">OF INFECTIOUS DESEASES</ins></h2></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <p class="HomeMisdiagnosisP">Infectious diseases <del class="diffchange diffchange-inline">including dengue fever, </del>typhoid fever, <del class="diffchange diffchange-inline">and </del>meningitis <del class="diffchange diffchange-inline">are symptomatically </del>similar <del class="diffchange diffchange-inline">to </del>malaria, <del class="diffchange diffchange-inline">and </del>thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. <del class="diffchange diffchange-inline">The lack of reliable rapid diagnostic tests </del>to <del class="diffchange diffchange-inline">diagnose diseases, </del>such <del class="diffchange diffchange-inline">as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these </del>diseases <del class="diffchange diffchange-inline">contribute significantly to the problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite </del>a <del class="diffchange diffchange-inline">lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients</del>, in <del class="diffchange diffchange-inline">addition to a loss of faith in established health services. Misdiagnosis can also result in increased </del>economic <del class="diffchange diffchange-inline">burdens </del>and <del class="diffchange diffchange-inline">anti-malarial drug resistance</del>. In <del class="diffchange diffchange-inline">Sudan</del>, the <del class="diffchange diffchange-inline">2000 annual cost </del>of <del class="diffchange diffchange-inline">both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria</del>.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <p class="HomeMisdiagnosisP">Infectious diseases <ins class="diffchange diffchange-inline">such as </ins>typhoid fever, meningitis<ins class="diffchange diffchange-inline">, pneumonia and visceral leishmaniasis have </ins>similar <ins class="diffchange diffchange-inline">clinical manifestations as </ins>malaria, thus are <ins class="diffchange diffchange-inline"><b></ins>often misdiagnosed<ins class="diffchange diffchange-inline"></b> </ins>in resource-poor developing countries lacking suitable medical diagnostic facilities. <ins class="diffchange diffchange-inline">Failure </ins>to <ins class="diffchange diffchange-inline">properly identify </ins>such diseases <ins class="diffchange diffchange-inline">prevents medical professionals from administering appropriate treatments in </ins>a <ins class="diffchange diffchange-inline">timely manner</ins>, <ins class="diffchange diffchange-inline">which results </ins>in economic <ins class="diffchange diffchange-inline">costs </ins>and <ins class="diffchange diffchange-inline">human suffering</ins>. In <ins class="diffchange diffchange-inline">order to address this issue</ins>, the <ins class="diffchange diffchange-inline">iGEM 2014 team is developing a <b>novel, genome-based, rapid point-</ins>of<ins class="diffchange diffchange-inline">-care synthetic biological device</b> to simultaneously diagnose multiple infectious diseases</ins>.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></section></div></td></tr>
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</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=388016&oldid=prevWkeithvan at 02:20, 18 October 20142014-10-18T02:20:11Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Black" id="HomeBsDetector"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Black" id="HomeBsDetector"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <img src="<del class="diffchange diffchange-inline">Robot</del>.png" id="HomeRobot"></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <img src="<ins class="diffchange diffchange-inline">https://static.igem.org/mediawiki/2014/2/28/2014UCalgaryHomeRobot</ins>.png" id="HomeRobot"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> DETECTOR</h2></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> DETECTOR</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></div></td></tr>
</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=387565&oldid=prevWkeithvan at 02:16, 18 October 20142014-10-18T02:16:05Z<p></p>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><section class="Content Text Color-Black" id="HomeBsDetector"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <img src="Robot.png" id="HomeRobot"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <h2 class="HomeBsDetectorH2" style="font-size: 60px;"><i style="font-size: 60px;">B.s.</i> DETECTOR</h2></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <p class="HomeBsDetectorP">We are developing a novel, genome-based, point-of-care synthetic biological device to <b>simultaneously diagnose multiple infectious diseases</b> that are prevalent worldwide.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></section></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><section class="Content Text Color-Light" id="HomeMisdiagnosis"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <h2 class="HomeMisdiagnosisH2">MALARIA MISDIAGNOSIS</h2></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <p class="HomeMisdiagnosisP">Infectious diseases including dengue fever, typhoid fever, and meningitis are symptomatically similar to malaria, and thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. The lack of reliable rapid diagnostic tests to diagnose diseases, such as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these diseases contribute significantly to the problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite a lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients, in addition to a loss of faith in established health services. Misdiagnosis can also result in increased economic burdens and anti-malarial drug resistance. In Sudan, the 2000 annual cost of both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></section></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> <h2 class="HomeMisdiagnosisH2">MALARIA MISDIAGNOSIS</h2></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><section class="Content Text Color-Orange" id="HomeCaseStudy"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> <p class="HomeCaseStudyP">Infectious diseases including dengue fever, typhoid fever, and meningitis are symptomatically similar to malaria, and thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. The lack of reliable rapid diagnostic tests to diagnose diseases, such as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these diseases contribute significantly to the problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite a lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients, in addition to a loss of faith in established health services. Misdiagnosis can also result in increased economic burdens and anti-malarial drug resistance. In Sudan, the 2000 annual cost of both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria.</p></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><h2 class="HomeCaseStudyH2">CASE STUDY</h2></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </section></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></section></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><section class="Content Text Color-Orange" id="HomeCaseStudy"></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman"></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><h2 class="HomeCaseStudyH2">CASE STUDY</h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> <section class="Content Text Color-Light" id="HomeOurDevice"></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> <h2 class="HomeOurDeviceH2">OUR DEVICE, OUR IDEA</h2></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> <p class="HomeOurDeviceP">iGEM Calgary 2014 team is using synthetic biology to develop a <span class="HomeBigText">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</span> device to simultaneously diagnose multiple infectious diseases.</p></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del></section></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><section class="Content Text Color-<del class="diffchange diffchange-inline">Blue</del>" id="<del class="diffchange diffchange-inline">HomeComponents</del>"></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><section class="Content Text Color-<ins class="diffchange diffchange-inline">Light</ins>" id="<ins class="diffchange diffchange-inline">HomeOurDevice</ins>"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><h2 class="<ins class="diffchange diffchange-inline">HomeOurDeviceH2</ins>">OUR <ins class="diffchange diffchange-inline">DEVICE, OUR IDEA</ins></h2<ins class="diffchange diffchange-inline">></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><h2 class="<del class="diffchange diffchange-inline">HomeComponentsH2</del>"><del class="diffchange diffchange-inline">COMPONENTS OF </del>OUR <del class="diffchange diffchange-inline">SYSTEM</del></h2></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <p class="HomeOurDeviceP">iGEM Calgary 2014 team is using synthetic biology to develop a <span class="HomeBigText">NOVEL, GENOME-BASED, RAPID POINT-OF-CARE</span> device to simultaneously diagnose multiple infectious diseases.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"></section</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><p class="HomeComponentsP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases is of particular concern.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"><section class="Content Text Color-Blue" id="HomeComponents"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <h2 class="HomeComponentsH2">COMPONENTS OF OUR SYSTEM</h2></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><p class="HomeComponentsP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which lack the resources to maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases is of particular concern.</p<ins class="diffchange diffchange-inline">></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"></section</ins>></div></td></tr>
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</table>Wkeithvanhttp://2014.igem.org/wiki/index.php?title=Team:Calgary&diff=298320&oldid=prevWkeithvan at 01:53, 17 October 20142014-10-17T01:53:50Z<p></p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 01:53, 17 October 2014</td>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">{{Team:Calgary/Main}}</ins></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><<del class="diffchange diffchange-inline">head></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><<ins class="diffchange diffchange-inline">section class</ins>="<ins class="diffchange diffchange-inline">Content Text Color-Light</ins>" <ins class="diffchange diffchange-inline">id</ins>="<ins class="diffchange diffchange-inline">HomeMisdiagnosis</ins>"></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><title>Calgary iGEM Home</title></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"></head></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><body align</del>="<del class="diffchange diffchange-inline">justify</del>"<del class="diffchange diffchange-inline">></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><p align</del>="<del class="diffchange diffchange-inline">center</del>"<del class="diffchange diffchange-inline">>Our website is under construction. Please check back later to see our complete page.</p></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><h1>Project Description</h1></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><p>Infectious diseases including dengue fever, typhoid fever, and meningitis are symptomatically similar to malaria, and thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. The lack of reliable rapid diagnostic tests to diagnose diseases, such as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these diseases contribute significantly to the problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite a lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients, in addition to a loss of faith in established health services. Misdiagnosis can also result in increased economic burdens and anti-malarial drug resistance. In Sudan, the 2000 annual cost of both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria diagnosis was approximately $14 million USD.</p</del>></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p><del class="diffchange diffchange-inline">To address this issue</del>, the iGEM Calgary 2014 team is using synthetic biology to develop a <del class="diffchange diffchange-inline">novel</del>, <del class="diffchange diffchange-inline">genome</del>-<del class="diffchange diffchange-inline">based</del>, <del class="diffchange diffchange-inline">rapid point</del>-<del class="diffchange diffchange-inline">of</del>-<del class="diffchange diffchange-inline">care </del>device to simultaneously diagnose multiple infectious diseases. <del class="diffchange diffchange-inline">We are engineering Bacillus subtilis to generate a chromophoric reporter protein in response to pathogenic genetic markers indicative of these </del>diseases<del class="diffchange diffchange-inline">. These synthetic organisms will lie dormant </del>as <del class="diffchange diffchange-inline">robust bacterial spores in a microfluidic device</del>, <del class="diffchange diffchange-inline">enabling users to input blood samples </del>and <del class="diffchange diffchange-inline">differentiate diseases based on colour of the output reporter proteins. Additionally</del>, <del class="diffchange diffchange-inline">our system is a platform technology </del>which <del class="diffchange diffchange-inline">can be adapted to detect a myriad of infectious agents by modifying </del>the <del class="diffchange diffchange-inline">disease markers </del>to <del class="diffchange diffchange-inline">which the system </del>is <del class="diffchange diffchange-inline">targeted</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <h2 class="HomeMisdiagnosisH2">MALARIA MISDIAGNOSIS</h2></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></<del class="diffchange diffchange-inline">body</del>></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><p <ins class="diffchange diffchange-inline">class="HomeCaseStudyP"</ins>><ins class="diffchange diffchange-inline">Infectious diseases including dengue fever</ins>, <ins class="diffchange diffchange-inline">typhoid fever, and meningitis are symptomatically similar to malaria, and thus are often misdiagnosed in resource-poor developing countries lacking suitable medical diagnostic facilities. The lack of reliable rapid diagnostic tests to diagnose diseases, such as typhoid fever and meningitis, and a reduced capacity to perform standard tests to accurately diagnose these diseases contribute significantly to </ins>the <ins class="diffchange diffchange-inline">problem of misdiagnosis. Due to these diagnostic challenges, patients can also undergo treatment for multiple diseases like malaria and typhoid fever despite a lack of confirmed diagnosis of co-infection. Improper treatment may prolong illness and cause adverse side effects in patients, in addition to a loss of faith in established health services. Misdiagnosis can also result in increased economic burdens and anti-malarial drug resistance. In Sudan, the 2000 annual cost of both treatment and diagnosis of malaria was $100 million USD whereas the calculated cost of accurate malaria.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </section></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <section class="Content Text Color-Orange" id="HomeCaseStudy"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <img src="https://static.igem.org/mediawiki/2014/d/d6/2014UCalgaryHomeHuman.png" id="HomeHuman"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <h2 class="HomeCaseStudyH2">CASE STUDY</h2></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <p class="HomeCaseStudyP">Prevalent infectious diseases such as meningitis, dengue and typhoid fever are symptomatically similar to malaria, and are thus often misdiagnosed in developing countries which <span class="HomeBigText">LACK THE RESOURCES</span> to maintain suitable healthcare infrastructures.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <p class="HomeCaseStudyP">Misdiagnosis prevents the appropriate treatments from being administered in a timely manner, which results in unnecessary <span class="HomeBigText">HUMAN SUFFERING</span> and a significant financial burden on the healthcare system.</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </section></ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <section class="Content Text Color-Light" id="HomeOurDevice"></ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <h2 class="HomeOurDeviceH2">OUR DEVICE, OUR IDEA</h2></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <p class="HomeOurDeviceP"></ins>iGEM Calgary 2014 team is using synthetic biology to develop a <ins class="diffchange diffchange-inline"><span class="HomeBigText">NOVEL</ins>, <ins class="diffchange diffchange-inline">GENOME</ins>-<ins class="diffchange diffchange-inline">BASED</ins>, <ins class="diffchange diffchange-inline">RAPID POINT</ins>-<ins class="diffchange diffchange-inline">OF</ins>-<ins class="diffchange diffchange-inline">CARE</span> </ins>device to simultaneously diagnose multiple infectious diseases.<ins class="diffchange diffchange-inline"></p></ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <section class="Content Text Color-Blue" id="HomeComponents"></ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <h2 class="HomeComponentsH2">COMPONENTS OF OUR SYSTEM</h2></ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> <p class="HomeComponentsP">Prevalent infectious </ins>diseases <ins class="diffchange diffchange-inline">such </ins>as <ins class="diffchange diffchange-inline">meningitis</ins>, <ins class="diffchange diffchange-inline">dengue </ins>and <ins class="diffchange diffchange-inline">typhoid fever are symptomatically similar to malaria</ins>, <ins class="diffchange diffchange-inline">and are thus often misdiagnosed in developing countries </ins>which <ins class="diffchange diffchange-inline">lack </ins>the <ins class="diffchange diffchange-inline">resources </ins>to <ins class="diffchange diffchange-inline">maintain suitable healthcare infrastructures (Murray, Quam, & Wilder-Smith, 2013). Failure to accurately diagnose such diseases </ins>is <ins class="diffchange diffchange-inline">of particular concern</ins>.</p></div></td></tr>
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