P2A

This is derived from the Porcine Teschovirus-1 genome and cleaves with high efficiency and leaving no scar following the formation of a polyprotein MS2 coat protein, P2A and RdRp. This is required as the HCV genome which has one open reading frame from which one long polyprotein is produced. RdRp is the final protein in this polygenic mRNA and hence does not have a start codon, adding a start codon could be disastrous for the function of RdRp.

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