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Team:Groningen/Template/MODULE/project/MBD/bandage
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Model-based bandage design
Our main goal for this project is to design a bandage prototype for burn wounds. Burn wounds are mainly infected with ''S. aureus'' and ''P. aeruginosa''. The quorum molecules produced by these two pathogens should diffuse through the bandage and activate the production of Nisin, Aiia and DspB proteins. These three proteins should diffuse out of the bandage and act on the pathogens.
Figure 4:
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To evaluate different bandage designs, we develop a multi-scale dynamic model of the bandage. The bandage is discretized into lattices where each lattice contains differential equations describing the growth of bacteria, production of nisin, production of Aiia, production of DspB and the detection of quorum molecules. Apart from the differential equations for the productions of the three IPM molecules we also consider the diffusion parameters. This makes the model more dynamic to study characteristics of our bandage. (Refer Figure 1 for all variables that are taken into account in the equations for each lattice).
