Team:MIT

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Improving the Diagnosis and Treatment of

ALZHEIMER'S DISEASE

Neurodegenerative Disease

Leading cause of death in the US

Current diagnosis and therapeutics are not effective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.

DETECTION → TREATMENT → DELIVERY

DETECTION
Native beta-amyloid receptor	Engineered B-cell receptor	miRNA sensors for Alzheimer’s state

TREATMENT	DELIVERY

Regulating beta-amyloid production and degradation	Delivering our circuit

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