Team:MIT

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[Dying Neuron] Neurodegenerative Disease	[6th] Leading cause of death in the US	[Vaccine] Current diagnosis and therapeutics are not effective

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, behavioral problems… There is currently no cure for this disease, and existing diagnosis methods leave much to be desired. MIT iGEM 2014 has set out to change this. By detecting molecular biomarkers for AD, such as miRNAs and neurotoxic beta-amyloid plaques, and by regulating the production of beta-amyloid plaques, MIT iGEM hopes to create a dynamic solution for patients with Alzheimer’s disease. Looking ahead, … delivery.
DETECT → TREAT → DELIVER

Detection
[LilRB2/PirB] Natural AB receptor	[BCR] Engineered AB receptor	[miRNA] Sensors for Alzheimer’s state

TREATMENT
[APP]
Regulate AB production
and degredation

Future
[Virus] Ways to deliver our circuit	[Survey] Public Opinion Survey