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Team:Paris Bettencourt/Project/Foot Odor
From 2014.igem.org
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AIMS Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
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BIOBRICKS Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras elementum mauris interdum lacus venenatis aliquet. In ac nulla semper, convallis orci non, vestibulum nisi. Maecenas quis ultricies tellus. |
| Introduction | Aims | Part3 | Part4 | Part5 |
Introduction
Bacillus subtilis is a bacterium which is commonly found in the foot flora. This bacterium produces isovaleric acid through leucine degradation pathway. As a consequence of this bad foot odor was produced.
Aims
The aim of this sub-project is to produce Bacillus subtilis, which lacks the capability of producing isovaleric acid and hence the bad foot odor.
Results
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed sit amet laoreet metus, ac viverra dolor. Sed et orci imperdiet sem vulputate ultricies. Aliquam erat volutpat. Cras semper ex non odio aliquet, eget feugiat eros tempor. Integer hendrerit odio et bibendum maximus. Duis scelerisque lacus in odio faucibus fringilla. Nulla eleifend aliquet molestie. Morbi aliquam rhoncus efficitur. Proin consectetur augue aliquam risus convallis egestas. Nunc viverra felis non nibh consequat, nec faucibus ipsum rutrum. Proin placerat faucibus libero vitae dapibus.
Motivation
We hypothesize that bad foot odor could be eradicated by perturbing the Leucine degradation pathway. We choose leucine dehydrogenase and iso-valeryl coA to perturb the leucine degradation pathway. Our goal here is to have two different strategies to inhibit isovaleric acid production. our first strategy focus on producing B.subtilis which will not be capable of producing leucine, so that it has to utilize all the leucine it could get from the sweat for its own survival rather than the production of isovaleric acid. Our second strategy focus on developing B.subtilis strain, which will be capable of producing leucine but not isovaleric acid.
