"

From 2014.igem.org

Cat-1 im Allgemeinen *check*

Probleme, die beim Fehlen von CAT-1 auftreten *check*

CAT-1 als Eintrittspunkt für Viren – Aufbau, wichtige Stellen

Spezifität der Viren auf diesen Rezeptor zeigt sich durch Probleme der Infektion bei Veränderung des Rezeptors

 

mouse cationic amino acid transporter 1 (mCAT-1)

Natural function

Transporters of the CAT-family form a class of proteins that occur in mammalian cells as a subfamily of the solute carrier family 7 (SLC7). Expressed nearly ubiquitiously in the body,  they catalyze the bidirectional transport of cationic amino acids through the cell membrane including the essential amino acids Lysine and Arginine. The central importance of this process becomes evident, if i.e. mCAT-1 (SLC7A1) is deleted by knock-out leading to death at the first day after birth. In several studies it was shown that this transporter is necessary for basic cell functions such as protein synthesis, nitric oxide synthesis and interorgan amino acid flow. Additionally, it plays a key role in recovery after cell stress as it allows for growth as soon as amino acids become available again.

In terms of the structure of mCAT-1 it is predicted to exhibit 14 transmembrane domains with intracellular N- and C-termini. The

 

 

mCAT-1 as viral entry side

 

[1]: